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Vol. 11, No. 4, 1984
Issue release date: 1984
Section title: Biological Psychology/Pharmacopsychology
Neuropsychobiology 1984;11:255–259
(DOI:10.1159/000118090)

A Comparison of Temazepam and Flurazepam in Terms of Sleep Quality and Residual Changes in Performance

Wesnes K. · Warburton D.M.
Department of Psychology, University of Reading, England

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychology/Pharmacopsychology

Published online: 2/19/2008
Issue release date: 1984

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

This study compared the effects of single nightly doses of flurazepam 30 mg and temazepam 40 mg upon both the subjective assessment of sleep quality and performance on 3 tests of mental efficiency 10 h following medication. 12 male and 12 female non-smoker subjects took part, none of whom experienced sleep difficulties. In comparison with their respective placebos, both hypnotics produced marked and significant improvements in the quality, depth and duration of sleep, and reduced the difficulty that the female subjects experienced in getting to sleep. Flurazepam also produced a significant increase in satisfaction with sleep together with significant reductions in the number of awakenings during the night and the level of clearheadedness on waking. The major test of performance was a continuous 20-min rapid visual information processing task. It was found that for both sexes during each of the two consecutive 10-min periods of performance flurazepam produced highly significant residual impairments in both the speed of reaction and the accuracy of detection, while temazepam had no effect. Overall the results indicate that flurazepam produces a wider range of improvements in sleep quality than temazepam at the cost of less clearheadedness on waking and residual impairments in sustained rapid information processing.


  

Author Contacts

K. Wesnes, Department of Psychology, University of Reading, Reading RG6 2AL (England)

  

Article Information

Number of Print Pages : 5

  

Publication Details

Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)

Vol. 11, No. 4, Year 1984 (Cover Date: 1984)

Journal Editor: Strik, W. (Bern)
ISSN: 0302–282X (Print), eISSN: 1423–0224 (Online)

For additional information: http://www.karger.com/NPS


Article / Publication Details

First-Page Preview
Abstract of Biological Psychology/Pharmacopsychology

Published online: 2/19/2008
Issue release date: 1984

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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