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Table of Contents
Vol. 25, No. 1, 1992
Issue release date: 1992
Section title: Biological Psychiatry
Neuropsychobiology 1992;25:1–7
(DOI:10.1159/000118800)

Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Schizophrenia: Association with Clinical Features

Kaneko M. · Yokoyama F. · Hoshino Y. · Takahagi K. · Murata S. · Watanabe M. · Kumashiro H.
Department of Neuropsychiatry, Fukushima Medical College, Fukushima City, Japan

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry

Published online: February 21, 2008
Issue release date: 1992

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

The function of the hypothalamic-pituitary-adrenal axis (HPA-axis) and its association with clinical features in chronic schizophrenia were investigated. Twenty of 33 chronic schizophrenics exhibited an abnormal diurnal variation of the saliva cortisol level. The patients with abnormal diurnal variation gave higher scores for some negative symptoms than those with normal diurnal variation. On the dexamethasone suppression test (DST) of saliva samples, 13 of 34 chronic schizophrenics were abnormal. The patients with DST nonsuppression were more frequently classified into disorganized type and exhibited low scores of anxiety compared with the patients with normal suppression. The 9 patients who showed abnormal diurnal variation and DST nonsuppression were more frequently classified into disorganized type and showed higher scores of negative symptoms than the 9 patients who did not show any abnormal cortisol data. These results suggest that there might be some disturbance in the function of the HPA-axis in a group of chronic schizophrenics and that these patients might have severe negative symptoms.

© 1992 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry

Published online: February 21, 2008
Issue release date: 1992

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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