Journal Mobile Options
Table of Contents
Vol. 26, No. 4, 1992
Issue release date: 1992
Add to my selection Citation Download
Neuropsychobiology 1992;26:210–217
(DOI:10.1159/000118923)
Pharmacoelectroencephalography

Topographical Analysis of Sleep Spindle Activity

Jobert M.a · Poiseau E.a,b · Jähnig P.a · Schulz H.a,c · Kubicki S.c
aAFB-Parexel, Arzneimittelforschung, GmbH, Europa Center, Berlin, FRG; bURA 817, University of Compiègne, France; cLaboratory of Clinical Psychophysiology, Department of Clinical Psychiatry, Free University of Berlin, FRG Neuropsychobiology 1992;26:210–217 (DOI:10.1159/000118923)

Abstract

There is evidence for two types of sleep spindle activity, one with a frequency of about 12 cycles/s (cps) and the other of about 14 cps. Visual examination indicates that both spindle types occur independently, whereby the 12-cps spindles are more pronounced in the frontal and the 14-cps spindles in the parietal region. The purpose of this paper is to provide more information about the exact topography of these patterns. First the occurrence of distinct signals in anterior and posterior brain regions was verified using pattern recognition techniques based on matched filtering. Thus the existence of two distinct sources of activity located in the frontal and parietal region of the brain, respectively, was demonstrated using EEG frequency mapping. Evaluation of sleep recordings showed high stability both in the frequency and location of the presumed spindle generators across sleep. Pharmacological effects of lormetazepam and zopiclone on both spindle types were investigated. Both substances enhanced the sleep spindle activity recorded from the frontal and parietal electrodes, but this increase was more pronounced in the parietal brain region.

 goto top of outline Author Contacts

Dr.-Ing. Marc Jobert, AFB-Parexel, Arzneimittelforschung GmbH in Berlin, Department of Biosignal Processing, Europa Center, D-W-1000 Berlin 30 (FRG)


 goto top of outline Article Information

Number of Print Pages : 8


 goto top of outline Publication Details

Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)

Vol. 26, No. 4, Year 1992 (Cover Date: 1992)

Journal Editor: Strik W. (Bern)
ISSN: 0302–282X (Print), eISSN: 1423–0224 (Online)

For additional information: http://www.karger.com/NPS


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.