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Vol. 26, No. 4, 1992
Issue release date: 1992
Neuropsychobiology 1992;26:210–217

Topographical Analysis of Sleep Spindle Activity

Jobert M.a · Poiseau E.a,b · Jähnig P.a · Schulz H.a,c · Kubicki S.c
aAFB-Parexel, Arzneimittelforschung, GmbH, Europa Center, Berlin, FRG; bURA 817, University of Compiègne, France; cLaboratory of Clinical Psychophysiology, Department of Clinical Psychiatry, Free University of Berlin, FRG


There is evidence for two types of sleep spindle activity, one with a frequency of about 12 cycles/s (cps) and the other of about 14 cps. Visual examination indicates that both spindle types occur independently, whereby the 12-cps spindles are more pronounced in the frontal and the 14-cps spindles in the parietal region. The purpose of this paper is to provide more information about the exact topography of these patterns. First the occurrence of distinct signals in anterior and posterior brain regions was verified using pattern recognition techniques based on matched filtering. Thus the existence of two distinct sources of activity located in the frontal and parietal region of the brain, respectively, was demonstrated using EEG frequency mapping. Evaluation of sleep recordings showed high stability both in the frequency and location of the presumed spindle generators across sleep. Pharmacological effects of lormetazepam and zopiclone on both spindle types were investigated. Both substances enhanced the sleep spindle activity recorded from the frontal and parietal electrodes, but this increase was more pronounced in the parietal brain region.

 goto top of outline Author Contacts

Dr.-Ing. Marc Jobert, AFB-Parexel, Arzneimittelforschung GmbH in Berlin, Department of Biosignal Processing, Europa Center, D-W-1000 Berlin 30 (FRG)

 goto top of outline Article Information

Number of Print Pages : 8

 goto top of outline Publication Details

Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)

Vol. 26, No. 4, Year 1992 (Cover Date: 1992)

Journal Editor: Strik W. (Bern)
ISSN: 0302–282X (Print), eISSN: 1423–0224 (Online)

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