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Vol. 45, No. 4, 2008
Issue release date: June 2008
Section title: Research Paper
J Vasc Res 2008;45:323–332
(DOI:10.1159/000119095)

Sympathetic Innervation of Human Mesenteric Artery and Vein

Birch D.J. · Turmaine M. · Boulos P.B. · Burnstock G.
aAutonomic Neuroscience Centre, and bDepartment of Surgery, Royal Free and University College Medical School, and cDepartment of Anatomy, University College London, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Research Paper

Received: 7/13/2007
Accepted: 11/24/2007
Published online: 3/3/2008

Number of Print Pages: 10
Number of Figures: 6
Number of Tables: 2

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR

Abstract

Background: Innervation of blood vessels shows inter-species variability. There are few studies on the innervation of human vessels; thus, healthy mesenteric vessels were studied to identify the expression of immunomarkers and the morphology of sympathetic innervation as the basis for a study of mesenteric vessels in inflammatory bowel disease. Methods and Results: Electron microscopy studies examined the relationships of nerves to smooth muscle cells. In veins, nerves were distributed throughout the medial smooth muscle coat, often in close apposition (50 nm) to smooth muscle cells. In arteries, nerves were located at the adventitial-medial border, few closer than 2,000 nm to smooth muscle cells, often with interposing connective tissue and Schwann cell processes. There was a significantly greater nerve density in veins than in arteries (227 vs. 41 mm2; p = 0.03). Immunohistochemical studies revealed the presence of sympathetic and sensory-motor nerves in arteries and veins. Conclusions: It is suggested that in humans with an upright stance, the mesenteric venous system plays a particularly important role in controlling mesenteric capacitance, which is reflected by their dense innervation. It is speculated that transmitters released from perivascular nerves supplying the human mesenteric arteries may play a long-term (trophic) role in addition to short-term signalling roles.


  

Author Contacts

Prof. Geoffrey Burnstock
Autonomic Neuroscience Centre, Royal Free and University College Medical School
Rowland Hill Street
London NW3 2PF (UK)
Tel. +44 20 7830 2948, Fax +44 20 7830 2949, E-Mail g.burnstock@ucl.ac.uk

  

Article Information

Received: July 13, 2007
Accepted after revision: November 24, 2007
Published online: March 3, 2008
Number of Print Pages : 10
Number of Figures : 6, Number of Tables : 2, Number of References : 29

  

Publication Details

Journal of Vascular Research (Incorporating 'International Journal of Microcirculation')

Vol. 45, No. 4, Year 2008 (Cover Date: June 2008)

Journal Editor: Pohl U. (Munich), Meininger G.A. (Columbia, Mo.)
ISSN: 1018–1172 (Print), eISSN: 1423–0135 (Online)

For additional information: http://www.karger.com/JVR


Article / Publication Details

First-Page Preview
Abstract of Research Paper

Received: 7/13/2007
Accepted: 11/24/2007
Published online: 3/3/2008

Number of Print Pages: 10
Number of Figures: 6
Number of Tables: 2

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR


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