Journal Mobile Options
Table of Contents
Vol. 45, No. 4, 2008
Issue release date: June 2008
Section title: Short Communication
J Vasc Res 2008;45:343–349
(DOI:10.1159/000119200)

Gene Expression during the Development of Experimentally Induced Cerebral Aneurysms

Sadamasa N.a, b · Nozaki K.b · Kita-Matsuo H.a · Saito S.a · Moriwaki T.b · Aoki T.b · Kawarazaki S.b · Kataoka H.b · Takagi Y.b · Ishikawa M.c · Hashimoto N.b · Kato K.a
aTaisho Laboratory of Functional Genomics, Nara Institute of Science and Technology, Nara, and Departments of Neurosurgery, bKyoto University Graduate School of Medicine, Kyoto, and cKitano Hospital, Osaka, Japan

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: 8/16/2006
Accepted: 11/24/2007
Published online: 3/4/2008
Issue release date: June 2008

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR

Abstract

Cerebral aneurysms are a major cause of subarachnoid hemorrhage, but the mechanism of their development remains unclear. In this study, we investigated candidate genes whose expression is significantly changed during the development of experimentally induced cerebral aneurysms using adaptor-tagged competitive polymerase chain reaction (ATAC-PCR). Twenty-four rats received sham operation (control) or the operation for the induction of experimental cerebral aneurysms. Rats were sacrificed at time 0, 2 weeks, 1 month and 3 months after the operation (n = 6 for each group). RNAs from right anterior cerebral artery/olfactory artery (ACA/OA) bifurcations were assessed via a 191-gene data matrix expression profile by ATAC-PCR. We identified 15 genes whose expression is significantly altered during cerebral aneurysm formation, including major heparan sulfate proteoglycan, cathepsin B, hevin and β4-integrin. We also confirmed protein expression of β4-integrin in rat cerebral aneurysms by quantitative real-time PCR and immunohistochemistry. The ATAC-PCR revealed temporal changes in gene expression during the development of experimental cerebral aneurysms. The genes that were significantly changed in this study would be the candidates for future studies concerning the development of cerebral aneurysms.

© 2008 S. Karger AG, Basel


  

Author Contacts

Dr. Kikuya Kato
Research Institute, Osaka Medical Center for Cancer and Cardiovascular Diseases
1-3-2 Nakamichi, Higashinari-ku
Osaka, 537-8511 (Japan)
Tel./Fax +81 6 6973 1209, E-Mail katou-ki@mc.pref.osaka.jp

  

Article Information

Received: August 16, 2006
Accepted after revision: November 24, 2007
Published online: March 4, 2008
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 2, Number of References : 27

  

Publication Details

Journal of Vascular Research (Incorporating 'International Journal of Microcirculation')

Vol. 45, No. 4, Year 2008 (Cover Date: June 2008)

Journal Editor: Pohl U. (Munich), Meininger G.A. (Columbia, Mo.)
ISSN: 1018–1172 (Print), eISSN: 1423–0135 (Online)

For additional information: http://www.karger.com/JVR


Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: 8/16/2006
Accepted: 11/24/2007
Published online: 3/4/2008
Issue release date: June 2008

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.