Electron-Microscopic Investigation of Muscle Mitochondria in Chronic Fatigue SyndromePlioplys A.V. · Plioplys S.
aChronic Fatigue Syndrome Center and Department of Research, Mercy Hospital and Medical Center, and bDepartment of Neurology, University of Illinois, Chicago, Ill., USA
Patients with chronic fatigue syndrome (CFS) suffer from disabling physical and mental fatigue. Abnormalities in mitochondrial function can lead to fatigue and weakness. Ultrastructural mitochondrial abnormalities have been reported to be present in CFS patients. We obtained percutaneous needle muscle biopsies from 15 CFS patients and 15 age- and sex-matched controls. We investigated previously reported ultrastructural abnormalities in CFS: subsarcolemmal mitochondrial aggregates, intermyofibrillar mitochondrial aggregates, mitochondrial circumference, area, pleomorphism and the presence of compartmentalization of the inner mitochondrial membrane. All of the steps of tissue processing, electron microscopy and data abstracting and analysis were performed in a totally blinded fashion. All of our data were rigorously quantified. We found no difference in any of these studied parameters between CFS patients and controls. Although there is no ultrastructural mitochondrial abnormality in CFS patients, other lines of evidence suggest the presence of a possible functional mitochondrial abnormality.
Dr. Audrius V. Plioplys, Chronic Fatigue Syndrome Center, Mercy Hospital and Medical Center, Stevenson Expressway at King Drive, Chicago, IL 60616 (USA)
Number of Print Pages : 7
Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)
Vol. 32, No. 4, Year 1995 (Cover Date: 1995)
Journal Editor: Strik W. (Bern)
ISSN: 0302–282X (Print), eISSN: 1423–0224 (Online)
For additional information: http://www.karger.com/NPS