Journal Mobile Options
Table of Contents
Vol. 35, No. 4, 1997
Issue release date: 1997
Section title: Pharmacoelectroencephalography
Neuropsychobiology 1997;35:211–220
(DOI:10.1159/000119347)

Comparison of the EEG Effects of Midazolam, Thiopental, and Propofol: The Role of Underlying Oscillatory Systems

Feshchenko V.A. · Veselis R.A. · Reinsel R.A.
aDepartment of Anesthesiology and Critical Care Medicine, Memorial Sloan-Kettering Cancer Center, and bCornell University Medical College, New York, N.Y., USA

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Pharmacoelectroencephalography

Published online: 2/26/2008
Issue release date: 1997

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

The EEG effects of 3 intravenous sedative drugs from different chemical families were studied during conscious sedation in 47 normal volunteers. The drugs studied were midazolam (a benzodiazepine), propofol (an alkylphenol) and thiopental (a barbiturate). Though these drugs cause different degrees of amnesia, they have the common EEG effects of suppressing α-rhythm and increasing total β-power. A large portion of the increase in β-power can be accounted for by β-rhythms. We used the UNIFAC-EEG technique to differentiate oscillatory systems underlying the rhythms induced by these drugs in a quantitative fashion. While thiopental induced β-rhythms which were similar to those appearing during drowsiness, midazolam and propofol induced β-rhythms with substantially different characteristics. The differences between the β-rhythms induced by drug infusion and previously described ‘sleep spindles’ are discussed. We conclude that a quantitative analysis of β-rhythms can differentiate the effects of these drugs on the EEG.


  

Author Contacts

Vladimir A. Feshchenko, PhD, Dept. Anesthesiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 (USA) Tel. (212) 639-6523, Fax (212) 772-8646, E-Mail 73071.640@COMPUSERVE.COM

  

Article Information

Number of Print Pages : 10

  

Publication Details

Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)

Vol. 35, No. 4, Year 1997 (Cover Date: 1997)

Journal Editor: Strik W. (Bern)
ISSN: 0302–282X (Print), eISSN: 1423–0224 (Online)

For additional information: http://www.karger.com/NPS


Article / Publication Details

First-Page Preview
Abstract of Pharmacoelectroencephalography

Published online: 2/26/2008
Issue release date: 1997

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.