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Vol. 23, No. 2, 1990/1991
Issue release date: 1990/1991
Section title: Biological Psychiatry
Neuropsychobiology 1990–91;23:57–67
(DOI:10.1159/000119428)

Psychometric, Polysomnographic, and Neuroendocrine Measures in Subjects at High Risk for Psychiatric Disorders: Preliminary Results

Krieg J.-C. · Lauer C.J. · Hermle L. · von Bardeleben U. · Pollmächer T. · Holsboer F.
Department of Psychiatry, University of Freiburg, FRG

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry

Published online: 2/27/2008
Issue release date: 1990/1991

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

We report on the psychometric, polysomnographic, and neuroendocrine status of 12 subjects at high familial risk for psychiatric disorders and of 10 healthy subjects not at high risk. The psychometric measurements in the high-risk probands revealed an accentuated ‘stress personality’ pattern and an increased neuroticism score. Their all-night EEG sleep tended to be shallower than that of the control subjects (i.e., decreased sleep efficiency, more frequent awakenings, less slow-wave sleep), whereas they did not differ on REM sleep parameters. The challenge of the limbic-hypothalamic-pituitary-adrenocortical system with corticotropin-releasing hormone after pretreatment with dexamethasone yielded no differences in cortisol secretion between the groups. On an intraindividual level, however, all subjects at high risk except one were found to be conspicuous in at least one of the three states examined.

© 1991 S. Karger AG, Basel


  

Author Contacts

PD Dr. J.-C. Krieg, Max Planck Institute of Psychiatry, Clinical Institute, Kraepelinstrasse 10, D-8000 Munich 40 (FRG)

  

Article Information

Number of Print Pages : 11

  

Publication Details

Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)

Vol. 23, No. 2, Year 1990/1991 (Cover Date: 1991)

Journal Editor: Strik W. (Bern)
ISSN: 0302–282X (Print), eISSN: 1423–0224 (Online)

For additional information: http://www.karger.com/NPS


Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry

Published online: 2/27/2008
Issue release date: 1990/1991

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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