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Vol. 25, No. 4, 2008
Issue release date: April 2008
Section title: Original Research Article
Dement Geriatr Cogn Disord 2008;25:347–353
(DOI:10.1159/000119594)

Neuroanatomical Correlates of Unawareness of Memory Deficits in Early Alzheimer’s Disease

Hanyu H. · Sato T. · Akai T. · Shimizu S. · Hirao K. · Kanetaka H. · Iwamoto T. · Koizumi K.
Departments of aGeriatric Medicine and bRadiology, Tokyo Medical University, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 11/27/2007
Published online: 3/5/2008

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Background/Aims: To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer’s disease (AD). Methods: We compared regional perfusion deficits between AD patients with awareness (n = 19) and unawareness (n = 19). SPECT data were analyzed by statistical brain imaging method. Results: Statistical maps demonstrated a more extensive and severe reduction in perfusion in the unaware group than in the aware group. Quantitative analysis demonstrated a significant difference between the groups in the right subcallosal, anterior cingulate and cingulate gyri and left orbital, subcallosal, and anterior cingulate gyri. Conclusion: Functional damage to the inferior, medial and orbital frontal lobes as well as the anterior cingulate gyri may be associated with the lack of awareness in patients with early AD.


  

Author Contacts

Haruo Hanyu, MD
Department of Geriatric Medicine, Tokyo Medical University
6-7-1 Nishishinjuku Shinjuku-ku
Tokyo 160-0023 (Japan)
Tel. +81 3 3342 6111, Fax +81 3 3342 2305, E-Mail h-hanyu@tokyo-med.ac.jp

  

Article Information

Accepted: November 27, 2007
Published online: March 5, 2008
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 2, Number of References : 33

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 25, No. 4, Year 2008 (Cover Date: April 2008)

Journal Editor: Chan-Palay V. (New York, N.Y.)
ISSN: 1420–8008 (Print), eISSN: 1421–9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 11/27/2007
Published online: 3/5/2008

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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