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Table of Contents
Vol. 56, No. 4, 2007
Issue release date: April 2008
Section title: Original Paper
Neuropsychobiology 2007;56:197–207
(DOI:10.1159/000120625)

Effects of Dietary Caffeine on Topographic EEG after Controlling for Withdrawal and Withdrawal Reversal

Keane M.A. · James J.E. · Hogan M.J.
National University of Ireland, Galway, Ireland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 05, 2007
Accepted: December 05, 2007
Published online: March 13, 2008
Issue release date: April 2008

Number of Print Pages: 11
Number of Figures: 3
Number of Tables: 3

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

Background/Aims: Despite several decades of research into the effects of caffeine on EEG, few consistent findings have emerged. Notwithstanding the likelihood that differences in methodology may explain some of the inconsistency, confidence in the published findings is undermined by the failure in previous studies to control for the effects of caffeine withdrawal and withdrawal reversal. Methods: Participants (n = 22) alternated weekly between ingesting placebo and caffeine (1.75 mg/kg) 3 times daily for 4 consecutive weeks. EEG activity was measured at 32 sites during eyes closed, eyes open, and performance of a vigilance task. Results: Caffeine was found to have few and modest effects on EEG in the theta and alpha bandwidths, and no effects in the delta and beta bandwidths. Evidence was found of withdrawal, withdrawal reversal, and tolerance in relation to observed increases in theta power during task performance; withdrawal and withdrawal reversal in relation to increases in alpha power during all three behavioural conditions (eyes closed, eyes open, and task performance), and withdrawal-induced adverse effects in relation to aspects of subjective mood. Conclusion: The finding of similar increases in theta power following caffeine challenge and acute caffeine withdrawal casts doubt on whether caffeine may be viewed as having direct stimulant effects. Results could suggest that change in drug state, whether in the form of acute caffeine withdrawal or challenge, may be disruptive to electrophysiological activity in the brain.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 05, 2007
Accepted: December 05, 2007
Published online: March 13, 2008
Issue release date: April 2008

Number of Print Pages: 11
Number of Figures: 3
Number of Tables: 3

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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