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Table of Contents
Vol. 41, No. 3, 2008
Issue release date: April 2008
Section title: Original Paper
Psychopathology 2008;41:194–200
(DOI:10.1159/000120988)

Social and Communication Difficulties and Obsessive-Compulsive Disorder

Cullen B.a · Samuels J.a · Grados M.a · Landa R.a · Bienvenu O.J.a · Liang K.-Y.b · Riddle M.a · Hoehn-Saric R.a · Nestadt G.a
aDepartment of Psychiatry and Behavioral Sciences, School of Medicine and bDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Md., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 18, 2006
Accepted: March 07, 2007
Published online: March 13, 2008
Issue release date: April 2008

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0254-4962 (Print)
eISSN: 1423-033X (Online)

For additional information: http://www.karger.com/PSP

Abstract

Background: The relationship between pervasive developmental disorder (PDD) and obsessive-compulsive disorder (OCD) has not been extensively studied despite having some phenomenological features in common. Abnormal social and communication behaviors (pragmatic behaviors) are key components of PDD and are also part of the broader autism phenotype (BAP). In this study we sought to establish if there is any association between the presence of abnormal pragmatic behaviors and OCD and whether this association delineates a familial subtype of OCD. Sampling and Methods: As part of the Johns Hopkins OCD Family Study, 80 OCD case probands were recruited and matched with 73 control probands. Probands and their first-degree relatives were interviewed using the Schedule for Affective Disorders and Schizophrenia-Lifetime Anxiety and other diagnostic instruments. A Pragmatic Rating Scale (PRS) to assess pragmatic behaviors was completed by the examiner. Results: The PRS was completed on 395 subjects, of which 3% (n = 11) achieved a score of greater than 6. The prevalence of high PRS scores was significantly greater amongst case probands and relatives (5%) compared to control probands and relatives (0.5%, p = 0.011). In case relatives the prevalence of OCD was significantly higher in those relatives who had a family member with a high PRS score (p < 0.001). Conclusions: The presence of social and communication difficulties in members of OCD case families appears to identify a familial subtype of OCD that may be related to PDD and/or BAP. This study was limited to using the PRS to identify pragmatic behaviors in subjects with OCD.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 18, 2006
Accepted: March 07, 2007
Published online: March 13, 2008
Issue release date: April 2008

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0254-4962 (Print)
eISSN: 1423-033X (Online)

For additional information: http://www.karger.com/PSP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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