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Vol. 15, No. 2-3, 2008
Issue release date: August 2008
Section title: Paper
J Mol Microbiol Biotechnol 2008;15:199–211
(DOI:10.1159/000121331)

Enzymatic Detoxification of Cyanide: Clues from Pseudomonas aeruginosa Rhodanese

Cipollone R. · Ascenzi P. · Tomao P. · Imperi F. · Visca P.
aDipartimento di Biologia, Università ‘Roma Tre’; bIstituto Nazionale per le Malattie Infettive IRCCS ‘Lazzaro Spallanzani’, Roma, and cDipartimento di Medicina del Lavoro, Istituto Superiore per la Prevenzione e la Sicurezza sul Lavoro, Monteporzio Catone (Roma), Italy

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 7/28/2008

Number of Print Pages: 13
Number of Figures: 3
Number of Tables: 3

ISSN: 1464-1801 (Print)
eISSN: 1660-2412 (Online)

For additional information: http://www.karger.com/MMB

Abstract

Cyanide is a dreaded chemical because of its toxic properties. Although cyanide acts as a general metabolic inhibitor, it is synthesized, excreted and metabolized by hundreds of organisms, including bacteria, algae, fungi, plants, and insects, as a mean to avoid predation or competition. Several cyanide compounds are also produced by industrial activities, resulting in serious environmental pollution. Bioremediation has been exploited as a possible alternative to chemical detoxification of cyanide compounds, and various microbial systems allowing cyanide degradation have been described. Enzymatic pathways involving hydrolytic, oxidative, reductive, and substitution/transfer reactions are implicated in detoxification of cyanide by bacteria and fungi. Amongst enzymes involved in transfer reactions, rhodanese catalyzes sulfane sulfur transfer from thiosulfate to cyanide, leading to the formation of the less toxic thiocyanate. Mitochondrial rhodanese has been associated with protection of aerobic respiration from cyanide poisoning. Here, the biochemical and physiological properties of microbial sulfurtransferases are reviewed in the light of the importance of rhodanese in cyanide detoxification by the cyanogenic bacterium Pseudomonas aeruginosa. Critical issues limiting the application of a rhodanese-based cellular system to cyanide bioremediation are also discussed.


  

Author Contacts

Paolo Visca
Dipartimento di Biologia
Universita Roma Tre, Viale G. Marconi 446
IT–00146 Roma (Italy)
Tel. +39 06 5733 6347, Fax +39 06 5733 6321, E-Mail visca@uniroma3.it

  

Article Information

Published online: July 28, 2008
Number of Print Pages : 13
Number of Figures : 3, Number of Tables : 3, Number of References : 91

  

Publication Details

Journal of Molecular Microbiology and Biotechnology

Vol. 15, No. 2-3, Year 2008 (Cover Date: August 2008)

Journal Editor: Saier Jr. M.H. (La Jolla, Calif.)
ISSN: 1464–1801 (Print), eISSN: 1660–2412 (Online)

For additional information: http://www.karger.com/MMB


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 7/28/2008

Number of Print Pages: 13
Number of Figures: 3
Number of Tables: 3

ISSN: 1464-1801 (Print)
eISSN: 1660-2412 (Online)

For additional information: http://www.karger.com/MMB


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