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Vol. 51, No. 1, 2008
Issue release date: April 2008
Section title: Original Paper
Intervirology 2008;51:59–68
(DOI:10.1159/000121363)

Hepatitis B Virus DNA in Liver Tissue and Risk for Hepatocarcinogenesis in Patients with Hepatitis C Virus-Related Chronic Liver Disease

A Prospective Study

Obika M.a · Shinji T.a · Fujioka S.a · Terada R.b · Ryuko H.a · Lwin A.A.a · Shiraha H.b · Koide N.a
Departments of aLaboratory Medicine, and bGastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/8/2007
Accepted: 4/2/2008
Published online: 3/18/2008
Issue release date: April 2008

Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 4

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT

Abstract

Aims: To prospectively study whether occult hepatitis B virus (HBV) infection can promote the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV)-related chronic liver disease. In addition, to evaluate the difference among HBV DNA-negative patients and patients with high and low HBV copy numbers. Methods: A total of 167 patients with HCV-related chronic liver disease without HBV surface antigen (HBsAg) were studied. HBV DNA in liver tissue was determined using polymerase chain reaction (PCR). Results: HBV DNA was detected in 9 of 167 patients (5.4%) by single PCR and in 25 patients (15.0%) by nested PCR. HCC developed in 12 of 167 patients (7.2%). Ten of 142 HBV DNA-negative patients (7.0%) and 2 of 9 patients with a high HBV copy number (22.2%) developed HCC, whereas none of 16 patients with a low HBV copy number developed HCC. The incidence rate of HCC in patients with a high HBV copy number was significantly higher than in HBV DNA-negative patients and patients with low HBV copy number. Conclusion: A high amount of HBV DNA in liver tissue of HBsAg-negative patients with HCV-related liver disease might be associated with HCC development.

© 2008 S. Karger AG, Basel


  

Author Contacts

Mikako Obika, MD, Department of Laboratory Medicine
Okayama University Graduate School of Medicine
Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho
Okayama 700-8558 (Japan)
Tel. +81 86 235 7342, Fax +81 86 235 7345, E-Mail gmd16802@cc.okayama-u.ac.jp

  

Article Information

Received: October 8, 2007
Accepted after revision: February 4, 2008
Published online: March 18, 2008
Number of Print Pages : 10
Number of Figures : 2, Number of Tables : 4, Number of References : 57

  

Publication Details

Intervirology (International Journal of Basic and Medical Virology)

Vol. 51, No. 1, Year 2008 (Cover Date: April 2008)

Journal Editor: Liebert U.G. (Leipzig)
ISSN: 0300–5526 (Print), eISSN: 1423–0100 (Online)

For additional information: http://www.karger.com/INT


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/8/2007
Accepted: 4/2/2008
Published online: 3/18/2008
Issue release date: April 2008

Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 4

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT


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