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Table of Contents
Vol. 59, No. 1, 2000
Issue release date: June 2000
Section title: Laboratory/Clinical Translational Research
Oncology 2000;59:50–56
(DOI:10.1159/000012137)

Genetic Aberrations Detected by Comparative Genomic Hybridization in Ovarian Clear Cell Adenocarcinomas

Suehiro Y.a,d · Sakamoto M.a · Umayahara K.a,d · Iwabuchi H.a · Sakamoto H.b · Tanaka N.c · Takeshima N.c · Yamauchi K.c · Hasumi K.c · Akiya T.a · Sakunaga H.a · Muroya T.a · Numa F.d · Kato H.d · Tenjin Y.a · Sugishita T.a
aDepartment of Gynecology, Sasaki Institute, Kyoundo Hospital, Tokyo, bChromosome Research Center, Olympus Optical Co., Hachioji, cDepartment of Gynecology, Cancer Institute Hospital, Tokyo, and dDepartment of Obstetrics and Gynecology, Yamaguchi University School of Medicine, Ube, Japan

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Article / Publication Details

First-Page Preview
Abstract of Laboratory/Clinical Translational Research

Published online: June 30, 2000
Issue release date: June 2000

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 6

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Genetic abnormalities were detected by comparative genomic hybridization (CGH) in 12 ovarian clear cell adenocarcinomas. DNA sequence copy number abnormalities (CNAs) occurring in more than 20% of the cancers included increased copy numbers of 8q11-q13, 8q21-q22, 8q23, 8q24-qter, 17q25-qter, 20q13-qter and 21q22-qter and reduced copy numbers of 19p. Increases in copy numbers of 8q11-q13, 8q21-q22, 8q23 and 8q24-qter occurred more frequently in disease-free patients than in recurrent/non-surviving patients (p < 0.05). However, increases in copy numbers of 17q25-qter and 20q13-qter occurred more frequently in recurrent/non-surviving patients than in disease-free patients (p < 0.05). Furthermore, increases in copy numbers of 17q25-qter and 20q13-qter occurred together (p < 0.05). Additionally, there were negative correlations between increases in copy numbers of 8q21-q22 and 17q25-qter, and between 8q21-q22 and 20q13-qter (p < 0.05). It appears that ovarian clear cell adenocarcinomas can be classified into two subtypes, one being cancer with an increase in copy numbers of 8q and the other being cancer with increases in copy numbers of 17q25-qter and 20q13-qter.

© 2000 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Laboratory/Clinical Translational Research

Published online: June 30, 2000
Issue release date: June 2000

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 6

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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