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Table of Contents
Vol. 56, No. 4, 2007
Issue release date: April 2008
Section title: Original Paper
Editor's Choice -- Free Access
Neuropsychobiology 2007;56:216–219

Cerebellar Posterior Superior Vermis and Cognitive Cluster Scores in Drug-Naive Patients with First-Episode Schizophrenia

Okugawa G. · Nobuhara K. · Takase K. · Kinoshita T.
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
email Corresponding Author

Gaku Okugawa, MD, PhD

Department of Neuropsychiatry, Kansai Medical University

2-3-1 Shinmachi Hirakata

Osaka 573-1191 (Japan)

Tel. +81 72 804 0101, Fax +81 72 804 0166, E-Mail okugawa@hirakata.kmu.ac.jp

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Previously, we performed an MRI study that revealed smaller volumes of the subregions of the cerebellar vermis in men and women with chronic schizophrenia. An issue that arose from that study was whether similar structural changes in the cerebellum are found in patients with first-episode schizophrenia. In the present study, MRI scans were acquired from 14 drug-naive patients with first-episode schizophrenia and 16 healthy subjects, and used to measure the volumes of their cerebellar subregions. Positive symptom, negative symptom and cognitive cluster scores were attained using the Positive and Negative Syndrome Scale. Patients with first-episode schizophrenia had reduced volumes of the anterior vermis and posterior superior vermis compared with healthy subjects. We confirmed that there was a volume reduction of the cerebellar vermis in drug-naive patients with first-episode schizophrenia. Smaller volumes of the posterior superior vermis were associated with worse cognitive cluster scores in patients with first-episode schizophrenia.

© 2008 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 05, 2007
Accepted: January 22, 2008
Published online: April 02, 2008
Issue release date: April 2008

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

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