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Table of Contents
Vol. 30, No. 3, 2008
Issue release date: May 2008
Section title: Original Paper
Free Access
Neuroepidemiology 2008;30:161–166

Dietary Epidemiology of Essential Tremor: Meat Consumption and Meat Cooking Practices

Louis E.D.a-d · Keating G.A.e · Bogen K.T.e · Rios E.a · Pellegrino K.M.a · Factor-Litvak P.d
aG.H. Sergievsky Center, bDepartment of Neurology, and cTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, and dDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, N.Y., eEnergy and Environmental Directorate, Lawrence Livermore National Security, LLC, Livermore, Calif., USA
email Corresponding Author

Dr. Elan Louis

Unit 198, Neurological Institute

710 West 168th Street

New York, NY 10032 (USA)

Tel. +1 212 305 9194, Fax +1 212 305 1304, E-Mail edl2@columbia.edu

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Background/Aim: Harmane [1-methyl-9H-pyrido(3,4-b)indole] is a tremor-producing neurotoxin. Blood harmane concentrations are elevated in essential tremor (ET) patients for unclear reasons. Potential mechanisms include increased dietary harmane intake (especially through well-cooked meat) or genetic-metabolic factors. We tested the hypothesis that meat consumption and level of meat doneness are higher in ET cases than in controls. Methods: Detailed data were collected using the Lawrence Livermore National Laboratory Meat Questionnaire. Results: Total current meat consumption was greater in men with than without ET (135.3 ± 71.1 vs. 110.6 ± 80.4 g/day, p = 0.03) but not in women with versus without ET (80.6 ± 50.0 vs. 79.3 ± 51.0 g/day, p = 0.76). In an adjusted logistic regression analysis in males, higher total current meat consumption was associated with ET (OR = 1.006, p = 0.04, i.e., with 10 additional g/day of meat, odds of ET increased by 6%). Male cases had higher odds of being in the highest than lowest quartile of total current meat consumption (adjusted OR = 21.36, p = 0.001). Meat doneness level was similar in cases and controls. Conclusion: This study provides evidence of a dietary difference between male ET cases and male controls. The etiological ramifications of these results warrant additional investigation.

© 2008 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 26, 2007
Accepted: January 23, 2008
Published online: April 02, 2008
Issue release date: May 2008

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

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