Tobacco Smoking and Depression – Results from the WHO/ISBRA StudyWiesbeck G.A. · Kuhl H.-C. · Yaldizli Ö. · Wurst F.M.
aPsychiatric University Clinics, Basel, Switzerland; bChristian-Doppler-Clinic, Paracelsus Medical University, Salzburg, Austria
Aims: To elucidate the relationship between tobacco smoking and depression, and to estimate the impact of other substance dependencies. Design: Cross-sectional. Participants: A total of 1,849 men and women were interviewed face-to-face using a validated structured questionnaire. According to their tobacco smoking behavior, participants were grouped into never smokers, ex-smokers and current smokers. Measurements: Data were generated through the WHO/ISBRA study, an international multicenter study with a cross-sectional design. A standardized questionnaire was administered face-to-face by trained interviewers. Logistic regression analysis was used to predict depression. Results: There was a significant difference across the 3 smoking groups in the number of subjects who had major depression (DSM-IV) during their lifetime. The highest rate of depressives was found in current smokers (23.7%), the lowest rate in never smokers (6.2%), while the rate of those who had quit smoking (14.6%) was between both. In a logistic regression analysis, alcohol dependence (both current and during lifetime) as well as cocaine dependence were significant predictors of depression. However, the association between smoking and depression still remained statistically significant. Conclusions: This study adds support to the evidence that smoking is linked to depression. It also elucidates the importance of taking into account alcohol and cocaine dependence since they have a significant impact on the relationship between smoking and depression.
Prof. Dr. med. Gerhard A. Wiesbeck
University Psychiatric Clinics Basel
Wilhelm Klein-Strasse 27
CH–4025 Basel (Switzerland)
Tel. +41 61 325 5111, Fax +41 61 325 5583, E-Mail firstname.lastname@example.org
WHO/ISBRA Investigators: K.M. Conigrave, M. Dongier, H. Edenberg, C.J.P. Eriksson, M.L.O.S. Formigoni, B.F.Grant, A. Helander, P.L. Hoffman, K. Kiianmaa, T. Koyama, L. Legault, T.K. Li, M. Monteiro, T. Methuen, T. Saito, M. Salaspuro, J.B. Saunders, B. Tabakoff, S. Tufik, J.B. Whitfield, F.M. Wurst.
Received: September 5, 2007
Accepted after revision: January 25, 2008
Published online: April 18, 2008
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 4, Number of References : 27
Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)
Vol. 57, No. 1-2, Year 2008 (Cover Date: June 2008)
Journal Editor: Strik W. (Bern)
ISSN: 0302–282X (Print), eISSN: 1423–0224 (Online)
For additional information: http://www.karger.com/NPS