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Table of Contents
Vol. 32, No. 2, 1981
Issue release date: 1981
Section title: Original Paper
Neuroendocrinology 1981;32:92–95
(DOI:10.1159/000123137)

The Dexamethasone Suppression Test as a Measure of Hypothalamic-Pituitary Feedback Sensitivity and its Relationship to Behavioral Arousal

Kalin N.H. · Cohen R.M. · Kraemer G.W. · Risch S.C. · Shelton S. · Cohen M. · McKinney W.T. · Murphy D.L.
Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Md., and Wisconsin Primate Laboratory, University of Wisconsin, Madison, Wisc., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 08, 1980
Accepted: September 04, 1980
Published online: March 26, 2008
Issue release date: 1981

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN

Abstract

A nonhuman primate model was used to evaluate the value of the dexamethasone suppression test as an index of hypothalamic-pituitary-adrenal responsiveness to arousal. In 8 rhesus monkeys plasma cortisol was suppressed by dexamethasone in a dose-dependent fashion at doses between 0.75 and 33 μg/kg. A replication study was performed 5 months later using a single dexamethasone dose (17 μg/kg) known to produce maximal plasma cortisol suppression. This yielded highly correlated results (r = 0.91, p < 0.005) suggesting that dexamethasone suppressibility may be a stable characteristic of individual animals. In 9 other animals whose arousal responses to a stressful procedure (nasogastric tube insertion) had been rated daily over a previous 3-month period, baseline plasma cortisol levels and the percent suppression of plasma cortisol by dexamethasone were evaluated. Baseline plasma cortisol levels did not significantly correlate with the degree of dexamethasone-suppression and the mean arousal ratings within animals. However, the postdexamethasone percent of baseline cortisol did correlate significantly (r = 0.75, p < 0.025) with individual mean arousal ratings. These preliminary results suggest that assessment of the sensitivity of an individual’s hypothalamic-pituitary glucocorticoid feedback system may be a better predictor than its baseline cortisol concentrations of its degree of behavioral arousal to stress.

© 1981 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 08, 1980
Accepted: September 04, 1980
Published online: March 26, 2008
Issue release date: 1981

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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