Enhancement by Progesterone of 5-Hydroxytryptophan Inhibition of the Copulatory Response in the Female RatSietnieks A. · Meyerson B.J.
Department of Medical Pharmacology, University of Uppsala, Sweden
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Article / Publication Details
A study was made of the influence of different hormonal treatments used to induce copulatory behavior in ovariectomized female rats (lordosis behavior), on the effects of an endogenous increase of 5-HT or catecholamines achieved by DL-5-HTP and L-Dopa. The lordosis response (LR) has been shown to be inhibited by increased serotonergic and catecholaminergic neuronal activity. The 5-HT agonist lysergic acid diethylamide (LSD) has been found to inhibit the LR. This effect was recently shown to be enhanced by increasing doses of progesterone. In the present study it was demonstrated that the inhibitory effect of the 5-HT precursor 5-hydroxytryptophan was also potentiated by increased doses of progesterone. However, the effect of DL-5-HTP on spontaneous behaviors in an exploratory situation was not influenced by progesterone treatment. In contrast to the results with DL-5-HTP, progesterone had no modulating effects on the lordosis-inhibiting action of the catecholamine precursor levo-dopa. This selective effect on the influence of a progesterone-dependent response suggests a direct relationship between 5-HT mechanisms and the progesterone action involved in the LR. Possible mechanisms underlying the observed interactive effect of progesterone and serotonin on lordosis behavior, such as a progesterone-induced alteration of serotonergic transmission, are discussed.
© 1982 S. Karger AG, Basel
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.