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Vol. 37, No. 5, 1983
Issue release date: 1983
Section title: Original Paper
Neuroendocrinology 1983;37:317–320
(DOI:10.1159/000123568)

Zinc May Have a Physiological Role in Regulating Pituitary Prolactin Secretion

Login I.S.a · Thorner M.O.b · MacLeod R.M.b
aDepartment of Neurology and bDepartment of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Va., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/21/1983
Accepted: 4/20/1983
Published online: 3/27/2008
Issue release date: 1983

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN

Abstract

We studied the in vitro influence of physiologically relevant zinc concentrations on the pituitary synthesis and secretion of prolactin (Prl). Zinc in concentrations between 1 and 10 μM reduced Prl secretion and, to a milder extent, synthesis, but not basal or stimulated growth hormone (GH) or LH release. At a supraphysiological concentration of 100 μM, zinc markedly decreased Prl synthesis and secretion, but increased LH secretion. The ability of a physiological zinc concentration to influence Prl secretion suggests that this trace element may have a role in the in vivo regulation of Prl release.

© 1983 S. Karger AG, Basel


  

Author Contacts

Ivan S. Login, MD, Department of Neurology, University of Virginia School of Medicine, Charlottesville, VA 22908 (USA)

  

Article Information

Received:January 21, 1983
Accepted after revision: April 20, 1983
Published online: March 27, 2008
Number of Print Pages : 4

  

Publication Details

Neuroendocrinology (International Journal for Basic and Clinical Studies on Neuroendocrine Relationships)

Vol. 37, No. 5, Year 1983 (Cover Date: 1983)

Journal Editor: Millar R.P. (Edinburgh)
ISSN: 0028–3835 (Print), eISSN: 1423–0194 (Online)

For additional information: http://www.karger.com/NEN


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/21/1983
Accepted: 4/20/1983
Published online: 3/27/2008
Issue release date: 1983

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN


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