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Vol. 42, No. 2, 1986
Issue release date: 1986
Section title: Original Paper
Neuroendocrinology 1986;42:93–96
(DOI:10.1159/000124256)

Characteristics of the Receptors Which Mediate the Stimulation of ACTH Secretion by Vasopressin in Conscious Dogs

Schwartz J. · Reid I.A.
Department of Physiology, University of California, San Francisco, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/13/1984
Accepted: 2/21/1985
Published online: 4/1/2008
Issue release date: 1986

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN

Abstract

In order to characterize the receptors which mediate the adrenocorticotropic hormone (ACTH) response to vasopressin in conscious animals, plasma 11-hydroxycorticosteroid concentration was measured in conscious dogs during the infusion of vasopressin or structural analogs of vasopressin which exhibit selective antidiuretic or vasoconstrictor activity. Vasopressin (1.0 ng/kg/min for 60 min) increased mean arterial pressure, decreased heart rate and increased plasma corticosteroid concentration from 1.0 ± 0.2 to 2.2 ± 0.2 µg/dl (p < 0.001). A specific antagonist of the vasoconstrictor activity of vasopressin, d(CH2)5MeTyrAVP (10 µg/kg), completely blocked the cardiovascular and corticosteroid responses to vasopressin. A selective vasoconstrictor (V1) agonist, PheOrnOT (1.0 ng/kg/min), which produced the same cardiovascular responses as vasopressin, increased plasma corticosteroid concentration from 1.1+0.1 to 2.9 ±0.9 µg/dl (p < 0.005). In marked contrast, a selective antidiuretic (V1) agonist, dDAVP (1.0 ng/kg/min) had no effect on blood pressure, heart rate or plasma corticosteroid concentration. These results indicate that the stimulation of ACTH release by vasopressin in conscious dogs is mediated by receptors which resemble vasoconstrictor-type (V1) receptors rather than antidiuretic-type (V<) receptors.

© 1986 S. Karger AG, Basel


  

Author Contacts

Dr. Ian A. Reid, Department of Physiology, 762-S, University of California, San Francisco, CA 94143 (USA)

  

Article Information

Received: November 13, 1984
Accepted after revision: February 21, 1985
Published online: April 01, 2008
Number of Print Pages : 4

  

Publication Details

Neuroendocrinology (International Journal for Basic and Clinical Studies on Neuroendocrine Relationships)

Vol. 42, No. 2, Year 1986 (Cover Date: 1986)

Journal Editor: Millar R.P. (Edinburgh)
ISSN: 0028–3835 (Print), eISSN: 1423–0194 (Online)

For additional information: http://www.karger.com/NEN


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/13/1984
Accepted: 2/21/1985
Published online: 4/1/2008
Issue release date: 1986

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN


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