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Vol. 70, No. 3, 2008
Issue release date: April 2008
Section title: Original Paper
ORL 2008;70:189–194
(DOI:10.1159/000124293)

Expression of Glucose Transporter-1 and -3 in the Head and Neck Carcinoma – The Correlation of the Expression with the Biological Behaviors

Zhou S.a · Wang S.a · Wu Q.b · Fan J.c · Wang Q.a
Departments of aOtolaryngology and bStomatology and cResearch Institute of Infection Disease, First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang, PR China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/29/2007
Accepted: 2/7/2007
Published online: 4/9/2008
Issue release date: April 2008

Number of Print Pages: 6
Number of Figures: 6
Number of Tables: 2

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL

Abstract

Objective: The aim of this study was to determine the biological significance of glucose transporter (Glut)-1 and Glut-3 expression in head and neck carcinoma (HNC). Methods: We detected expression of Glut-1 and -3 in 38 HNCs and analyzed the relationship between increased expression and the biological behavior of HNCs. Results: The gene expression levels of Glut-1 and -3 in HNCs were significantly higher than those in adjacent cancer tissues or in normal tissues. The GLUT-1 gene level was correlated with the lymph node metastasis and clinical stage of 38 HNCs, and the GLUT-3 gene level was correlated with the lymph node metastasis of 38 HNCs. Of the 38 cases, 30 showed positive expression of Glut-1 protein. The Glut-1 protein expression level was related to the lymph node metastasis and clinical stage of 38 HNCs. However, there was no case that expressed Glut-3 protein. The high expression of Glut-1 gene and protein was associated with poor survival in the HNCs. GLUT-3 gene expression was not associated with the prognosis of HNCs. Conclusions:GLUT-1 gene expression level and protein expression were correlated with lymph node metastasis, poor survival and clinical stage of HNCs. The GLUT-3 gene expression level was high in HNCs, and its expression was associated with an increased incidence of lymph node metastasis of HNCs.

© 2008 S. Karger AG, Basel


  

Author Contacts

Shenqing Wang Department of Otolaryngology
First Affiliated Hospital, Medical College of Zhejiang University
Hangzhou, Zhejiang, 310003 (PR China)
Tel. +86 571 131 8421 5850, Fax +86 571 8723 6628, E-Mail shenqingwangzh@163.com

  

Article Information

Received: March 29, 2007
Accepted after revision: July 2, 2007
Published online: April 9, 2008
Number of Print Pages : 6
Number of Figures : 6, Number of Tables : 2, Number of References : 13

  

Publication Details

ORL (Journal for Oto-Rhino-Laryngology, Head and Neck Surgery)

Vol. 70, No. 3, Year 2008 (Cover Date: April 2008)

Journal Editor: O'Malley Jr. B.W. (Philadelphia, Pa.)
ISSN: 0301–1569 (Print), eISSN: 1423–0275 (Online)

For additional information: http://www.karger.com/ORL


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/29/2007
Accepted: 2/7/2007
Published online: 4/9/2008
Issue release date: April 2008

Number of Print Pages: 6
Number of Figures: 6
Number of Tables: 2

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL


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