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Table of Contents
Vol. 70, No. 3, 2008
Issue release date: April 2008
Section title: Original Paper
ORL 2008;70:189–194
(DOI:10.1159/000124293)

Expression of Glucose Transporter-1 and -3 in the Head and Neck Carcinoma – The Correlation of the Expression with the Biological Behaviors

Zhou S.a · Wang S.a · Wu Q.b · Fan J.c · Wang Q.a
Departments of aOtolaryngology and bStomatology and cResearch Institute of Infection Disease, First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang, PR China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 29, 2007
Accepted: February 07, 2007
Published online: April 09, 2008
Issue release date: April 2008

Number of Print Pages: 6
Number of Figures: 6
Number of Tables: 2

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL

Abstract

Objective: The aim of this study was to determine the biological significance of glucose transporter (Glut)-1 and Glut-3 expression in head and neck carcinoma (HNC). Methods: We detected expression of Glut-1 and -3 in 38 HNCs and analyzed the relationship between increased expression and the biological behavior of HNCs. Results: The gene expression levels of Glut-1 and -3 in HNCs were significantly higher than those in adjacent cancer tissues or in normal tissues. The GLUT-1 gene level was correlated with the lymph node metastasis and clinical stage of 38 HNCs, and the GLUT-3 gene level was correlated with the lymph node metastasis of 38 HNCs. Of the 38 cases, 30 showed positive expression of Glut-1 protein. The Glut-1 protein expression level was related to the lymph node metastasis and clinical stage of 38 HNCs. However, there was no case that expressed Glut-3 protein. The high expression of Glut-1 gene and protein was associated with poor survival in the HNCs. GLUT-3 gene expression was not associated with the prognosis of HNCs. Conclusions:GLUT-1 gene expression level and protein expression were correlated with lymph node metastasis, poor survival and clinical stage of HNCs. The GLUT-3 gene expression level was high in HNCs, and its expression was associated with an increased incidence of lymph node metastasis of HNCs.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 29, 2007
Accepted: February 07, 2007
Published online: April 09, 2008
Issue release date: April 2008

Number of Print Pages: 6
Number of Figures: 6
Number of Tables: 2

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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