Plasma Corticosterone Responses to Electrical Stimulation of the Amygdaloid Complex: Cytoarchitectural SpecificityDunn J.D. · Whitener J.
Department of Anatomy, Oral Roberts University, Tulsa, Okla., USA
To pursue the possibility that subdivisions within the amygdaloid complex are differentially involved in adrenocortical function, plasma samples obtained prior to and following electrical stimulation of the amygdala of urethane (1.30 g/kg) anesthetized female rats were assessed for corticosterone concentration. Hippocampal EEG, ECG, heart rate, mean arterial pressure, and respiration routinely were monitored, and timed blood samples (0.2 ml) were obtained from a catheterized artery. Blood samples were taken 0.5 min prior to and at 5, 10, 15, and 30 min after initiation of stimulation. Whereas stimulation of the central and lateral nuclei produced a decrease (p < 0.05) in plasma corticosterone, stimulation of the basomedial, medial and posterior corticomedial nuclei resulted in increased plasma corticosterone levels (p < 0.05). In contrast, no change in corticosterone levels were observed following sham stimulation or stimulation of several nonamygdaloid sites. Collectively, these data support the hypothesis that subdivisions within the amygdaloid complex are differentially involved in adrenocortical function.
Dr. Jon D. Dunn, Department of Anatomy, Schools of Medicine and Dentistry, Oral Roberts University, 7777 South Lewis, Tulsa, OK 74171 (USA)
Received: August 1, 1984
Accepted after revision: April 10, 1985
Published online: April 01, 2008
Number of Print Pages : 7
Neuroendocrinology (International Journal for Basic and Clinical Studies on Neuroendocrine Relationships)
Vol. 42, No. 3, Year 1986 (Cover Date: 1986)
Journal Editor: Millar R.P. (Edinburgh)
ISSN: 0028–3835 (Print), eISSN: 1423–0194 (Online)
For additional information: http://www.karger.com/NEN