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Vol. 45, No. 4, 1987
Issue release date: 1987
Section title: Original Paper
Neuroendocrinology 1987;45:305–310
(DOI:10.1159/000124754)

Differential Effects of Serotonin (5-HT1A and 5-HT2) Agonists and Antagonists on Renin and Corticosterone Secretion

Lorens S.A. · Van de Kar L.D.
Department of Pharmacology, Stritch School of Medicine, Loyola University of Chicago, Maywood, Ill., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/12/1986
Accepted: 10/31/1986
Published online: 4/2/2008
Issue release date: 1987

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN

Abstract

The present study was designed to investigate the effect of distinct serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion. Low doses of the selective 5-HT1A agonists 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT) (5.0–500.0 µg/kg, i.p.) and ipsapirone (TVX Q 7821; 0.5–2.5 mg/kg, i.p.), and of the 5-hy-droxytryptamine (5-HT) agonist MK-212 (2.0 mg/kg, i.p.), did not elevate plasma renin activity (PRA) and concentration (PRC) 30 min postinjection. Administration of a higher dose of MK-212 (10.0 mg/kg, i.p.) and of higher doses of ipsapirone (5.0–10.0 mg/kg, i.p.), as well as the 5-HT releaser, fenfluramine (5.0 mg/kg, i.p.), resulted in large increases in PRA and PRC. The effects of MK-212 and fenfluramine on PRA and PRC were blocked by pretreatment with the selective 5-HT2 antagonist, LY53857, in a dose-dependent (0.3–1.0 mg/kg, i.p.) manner. LY53857 (1.0 mg/kg, i.p.) by itself did not affect PRA or PRC. LY53857, furthermore, unmasked a renin-suppressive effect of MK-212, since injection of MK-212 (10.0 mg/kg, i.p.) following LY53857 administration led to a reduction in PRA and PRC. MK-212 (2.0 and 10.0 mg/kg), the high doses of 8-OH-DPAT (500.0 µg/kg), ipsapirone (1.0–10.0 mg/kg), and fenfluramine (5.0 mg/kg) all produced an increase in plasma corticosterone levels. The effects of MK-212 and fenfluramine on corticosterone were not inhibited by pretreatment with LY53857. These data suggest that 5-HTIA receptors do not play a role in the regulation of renin secretion, whereas stimulation of 5-HT2 receptors enhances renin release. The data also suggest that MK-212- and fenfluramine-induced corticosterone secretion is not mediated by 5-HT2 receptors.

© 1987 S. Karger AG, Basel


  

Author Contacts

L.D. Van de Kar, PhD, Department of Pharmacology, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 60153 (USA)

  

Article Information

Received: February 12, 1986
Accepted after revision: October 31, 1986
Published online: April 02, 2008
Number of Print Pages : 6

  

Publication Details

Neuroendocrinology (International Journal for Basic and Clinical Studies on Neuroendocrine Relationships)

Vol. 45, No. 4, Year 1987 (Cover Date: 1987)

Journal Editor: Millar R.P. (Edinburgh)
ISSN: 0028–3835 (Print), eISSN: 1423–0194 (Online)

For additional information: http://www.karger.com/NEN


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/12/1986
Accepted: 10/31/1986
Published online: 4/2/2008
Issue release date: 1987

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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