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Vol. 146, Suppl. 1, 2008
Issue release date: May 2008
Section title: Original Paper
Int Arch Allergy Immunol 2008;146:47–53
(DOI:10.1159/000126061)

Allergen-Induced Basophil CD203c Expression as a Biomarker for Rush Immunotherapy in Patients with Japanese Cedar Pollinosis

Nagao M.a · Hiraguchi Y.a · Hosoki K.a · Tokuda R.a · Usui T.b · Masuda S.b · Yamaguchi M.c · Fujisawa T.a
aInstitute for Clinical Research and bDepartment of Otorhinolaryngology, Mie National Hospital, Mie, and cDepartment of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 5/27/2008
Issue release date: May 2008

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: Rush immunotherapy (RIT) can confer rapid clinical benefit on patients with allergic rhinitis or asthma. However, biomarkers representing mechanisms for the efficacy of RIT are still to be established. CD203c is a basophil activation marker known to be upregulated by cross-linking of the FcεRIα receptor and may serve as a useful marker. Objective: We sought to investigate the changes in allergen-induced CD203c expression in patients with Japanese cedar pollen (JCP) pollinosis who received RIT. Methods: Nine patients treated with RIT were enrolled in the study. Whole blood was incubated with various concentrations of JCP extract. CD203c expression on basophils was quantitated by means of flow cytometry. JCP-specific IgG4 levels in sera were measured with ELISA. Basophil histamine release, CAP-RAST to JCP (JCP-IgE) and total IgE were also examined. The biomarkers listed above were evaluated before and sequentially after RIT. Symptom and quality of life scores were obtained during pre- and posttreatment pollen seasons. Results: All patients showed significant improvement in symptom and quality of life scores after RIT. Serum JCP-specific IgG4 titers were significantly elevated at 1 month and remained at high levels 12 months after the treatment. Stimulation with JCP extract induced enhancement of basophil CD203c expression in a concentration-dependent manner except for 2 subjects in whom no increase in CD203c by an anti-IgE antibody was observed (nonresponders). Significant reductions in the responses were observed in 4 subjects after RIT (reduction in CD203c expression, RCE) whereas no changes were seen in 3 subjects (non-RCE). RCE subjects were older than non-RCE counterparts, with mean ages of 20 and 12 years, respectively. No significant changes in JCP-specific IgE and total IgE levels were seen before and after RIT. Conclusion: Allergen-induced CD203c expression in basophils may represent, at least in part, the cellular mechanism for the therapeutic responses to RIT for JCP pollinosis. However, further larger-scale studies to confirm the utility of the test are necessary.

© 2008 S. Karger AG, Basel


  

Author Contacts

Correspondence to: Dr. Takao Fujisawa
Institute for Clinical Research, Mie National Hospital
357 Osato-kubota
Tsu, Mie 514-0125 (Japan)
Tel. +81 59 232 2531, Fax +81 59 232 5994, E-Mail fujisawa@mie-m.hosp.go.jp

  

Article Information

Published online: May 27, 2008
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 1, Number of References : 28

  

Publication Details

International Archives of Allergy and Immunology

Vol. 146, No. Suppl. 1, Year 2008 (Cover Date: May 2008)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018–2438 (Print), eISSN: 1423–0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 5/27/2008
Issue release date: May 2008

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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