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Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis: The GENEVA Study
Rationale, Study Design and Demographic CharacteristicsSchmidt S.a, b · Allen K.D.b, c · Loiacono V.T.a, b · Norman B.b, c · Stanwyck C.L.a, b · Nord K.M.a, b · Williams C.D.a, b · Kasarskis E.J.e · Kamel F.d · McGuire V.f · Nelson L.M.f · Oddone E.Z.b, c
aCenter for Human Genetics and bDepartment of Medicine, Duke University Medical Center, and cEpidemiology Research and Information Center, Durham VAMC, Durham, N.C., dEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, N.C., eLexington VAMC and University of Kentucky Medical Center, Lexington, Ky., and fStanford University School of Medicine, Stanford, Calif., USA Corresponding Author
Silke Schmidt, PhD
Center for Human Genetics, Department of Medicine
Duke University Medical Center, Box 3445
Durham, NC 27710 (USA)
Tel. +1 919 684 0624, Fax +1 919 684 0925, E-Mail firstname.lastname@example.org
Recent reports of a potentially increased risk of amyotrophic lateral sclerosis (ALS) for veterans deployed to the 1990–1991 Persian Gulf War prompted the Department of Veterans Affairs to establish a National Registry of Veterans with ALS, charged with the goal of enrolling all US veterans with a neurologist-confirmed diagnosis of ALS. The Genes and Environmental Exposures in Veterans with ALS study (GENEVA) is a case-control study presently enrolling cases from the Department of Veterans Affairs registry and a representative sample of veteran controls to evaluate the joint contributions of genetic susceptibility and environmental exposures to the risk of sporadic ALS. The GENEVA study design, recruitment strategies, methods of collecting DNA samples and environmental risk factor information are described here, along with a summary of demographic characteristics of the participants (537 cases, 292 controls) enrolled to date.
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