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Vol. 63, No. 3, 1996
Issue release date: 1996
Section title: Neuroimmune Interactions
Neuroendocrinology 1996;63:227–236
(DOI:10.1159/000126962)

Interleukin 6 Modulates lnterleukin-1– and Stress-Induced Activation of the Hypothalamic-Pituitary-Adrenal Axis in Male Rats

Zhou D.a · Shanks N.b · Riechman S.E.a · Liang R.a · Kusnecov A.W.a · Rabin B.S.a
aBrain, Behavior and Immunity Center and Division of Clinical Immunopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pa., USA; bUniversity of Bristol, Department of Medicine, Bristol Royal Infirmary Laboratories, Bristol, UK

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Article / Publication Details

First-Page Preview
Abstract of Neuroimmune Interactions

Received: 6/27/1995
Accepted: 11/2/1995
Published online: 4/9/2008
Issue release date: 1996

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN

Abstract

This study examined the interaction between interleukin 6 (IL-6) and IL-1 and between IL-6 and stress on the activation of the hypothalamic-pituitary-adrenal (HP A) axis. Coadministration of IL-6 (100 ng/rat) with IL-1 (20 or 100 ng/ rat) resulted in synergistic stimulation of the HPA axis, as determined by increased plasma levels of ACTH and corticosterone (CORT) which were greater in rats that received both cytokines than in rats receiving either cytokine alone. Concomitant administration of IL-6 (100 ng/rat) with exposure to a novelty stressor also synergistically stimulated the activation of the HPA axis, as IL·6-treated rats subjected to novelty stress had greater increases in plasma levels of ACTH and CORT than vehicle-treated rats exposed to novelty stress or rats receiving IL-6 alone. However, concomitant administration of IL-6 (100 ng/rat) did not significantly affect restraint stress induced elevation of plasma levels of ACTH and CORT, although IL-6 tended to prolong restraint stress induced elevation of plasma levels of CORT. These findings indicate a modulatory role for IL-6 stimulated HPA axis activity in response to IL-1 or a novelty psychological stressor, but not for restraint stress.

© 1996 S. Karger AG, Basel


  

Author Contacts

Daohong Zhou, MD, K528 Kentucky Clinic, Division of Allergy, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536-0284 (USA)

  

Article Information

Received: June 27, 1995
Accepted after revision: November 2, 1995
Published online: April 09, 2008
Number of Print Pages : 10

  

Publication Details

Neuroendocrinology (International Journal for Basic and Clinical Studies on Neuroendocrine Relationships)

Vol. 63, No. 3, Year 1996 (Cover Date: 1996)

Journal Editor: Millar R.P. (Edinburgh)
ISSN: 0028–3835 (Print), eISSN: 1423–0194 (Online)

For additional information: http://www.karger.com/NEN


Article / Publication Details

First-Page Preview
Abstract of Neuroimmune Interactions

Received: 6/27/1995
Accepted: 11/2/1995
Published online: 4/9/2008
Issue release date: 1996

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN


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