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Vol. 88, No. 2, 2008
Issue release date: August 2008
Section title: At the Cutting Edge
Neuroendocrinology 2008;88:80–87
(DOI:10.1159/000127319)

Role of VGF-Derived Peptides in the Control of Food Intake, Body Weight and Reproduction

Jethwa P.H. · Ebling F.J.P.
School of Biomedical Sciences and Institute of Neuroscience, University of Nottingham Medical School, Queen’s Medical Centre, Nottingham, UK

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Article / Publication Details

First-Page Preview
Abstract of At the Cutting Edge

Received: 12/21/2007
Accepted: 2/27/2008
Published online: 4/14/2008
Issue release date: August 2008

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN

Abstract

VGF is a 68-kDa polypeptide synthesized in neuronal and neuroendocrine cells. It is cleaved into a number of smaller peptides which are stored in dense core vesicles and are likely to be secreted products. The VGF gene is expressed abundantly in the brain, and in peripheral endocrine tissues including the pituitary gland, the adrenal glands and the pancreas but also in the gastrointestinal tract in both the myenteric plexus and in endocrine cells. Several lines of evidence including observation of changes in hypothalamic VGF expression in catabolic states, a hypermetabolic phenotype in transgenic mice lacking VGF signalling, and demonstration of bioactivity of various peptide fragments have led to the view that VGF and/or its derived peptides are involved in the regulation ofboth energy balance and reproduction.

© 2008 S. Karger AG, Basel


  

Author Contacts

Preeti H. Jethwa
School of Biomedical Sciences and Institute of Neuroscience
University of Nottingham Medical School, Queen Medical Centre
Nottingham NG7 2UH (UK)
Tel. +44 115 823 0154, Fax +44 115 823 0142, E-Mail preeti.jethwa@nottingham.ac.uk

  

Article Information

Received: December 21, 2007
Accepted after revision: February 27, 2008
Published online: April 14, 2008
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 0, Number of References : 41

  

Publication Details

Neuroendocrinology (International Journal for Basic and Clinical Studies on Neuroendocrine Relationships)

Vol. 88, No. 2, Year 2008 (Cover Date: August 2008)

Journal Editor: Millar R.P. (Edinburgh)
ISSN: 0028–3835 (Print), eISSN: 1423–0194 (Online)

For additional information: http://www.karger.com/NEN


Article / Publication Details

First-Page Preview
Abstract of At the Cutting Edge

Received: 12/21/2007
Accepted: 2/27/2008
Published online: 4/14/2008
Issue release date: August 2008

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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