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Vol. 43, No. 3, 1999
Issue release date: May–June 1999
Section title: Original Paper
Ann Nutr Metab 1999;43:173–180
(DOI:10.1159/000012783)

Cholesterol-Lowering Activity of Naringenin via Inhibition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Acyl Coenzyme A:Cholesterol Acyltransferase in Rats

Lee S.H. · Park Y.B. · Bae K.H. · Bok H. · Kwon Y.K. · Lee E.S. · Choi M.S.
aDepartment of Nutrition and Food Science and bDepartment of Genetic Engineering, Kyungpook National University, Taegu, cChungnam National University School of Pharmacy, Taejon, and dKorea Institute of Bioscience and Biotechnology, KIST, Taejon, South Korea

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 10/20/1999

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

The effects of dietary supplementation of a citrus bioflavonoid, naringenin, on the cholesterol metabolism were studied. For 42 days male rats were fed a 1% (wt/wt) high-cholesterol diet with or without a naringenin supplementation (0.1%, wt/wt) to study its effect on plasma lipid levels, hepatic lipid contents, activities of hepatic acyl coenzyme A:cholesterol O-acyltransferase (ACAT) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, and the excretion of fecal neutral sterols. Naringenin did not significantly alter the concentration of plasma triglycerides, but lowered the plasma cholesterol (3.80 vs. 3.12 mmol/l) concentration and the hepatic cholesterol content (70.3 vs. 54.0 mg/g) significantly (p < 0.05) compared to those of the controls. HMG-CoA reductase (1,879.0 vs. 1,715.0 pmol/min/mg) and ACAT activities (806.0 vs. 563.0 pmol/min/mg) were significantly lower in the naringenin-supplemented group than in controls. Naringenin supplementation caused a marked decrease in the excretion of fecal neutral sterols (242.9 mg/day) compared to the controls (521.9 mg/day). These results show that naringenin lowers the plasma and hepatic cholesterol concentrations by suppressing HMG-CoA reductase and ACAT in rats fed a high-cholesterol diet.


  

Author Contacts

M.S. Choi, PhD
Department of Nutrition and Food Science
Kyungpook National University, 702-701 Taegu (South Korea)
Tel. +82 53 950 6232, Fax +82 53 950 6229
E-Mail mschoi@kyungpook.ac.kr

  

Article Information

Received: Received: August 20, 1998
Accepted: February 28, 1999
Number of Print Pages : 8
Number of Figures : 2, Number of Tables : 3, Number of References : 47

  

Publication Details

Annals of Nutrition & Metabolism (European Journal of Nutrition, Metabolic Diseases and Dietetics)
Founded 1959 as ’Nutritio et Dieta‘ by E. Azerad, H. Kapp and J. Trémolières
Official Journal of the Federation of European Nutrition Societies (FENS)

Vol. 43, No. 3, Year 1999 (Cover Date: May-June 1999)

Journal Editor: G. Wolfram, Freising
ISSN: 0250–6807 (print), 1421–9697 (Online)

For additional information: http://www.karger.com/journals/anm


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 10/20/1999

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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