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Vol. 14, No. 3, 1982
Issue release date: 1982
Section title: Original Paper
Eur Surg Res 1982;14:221–230
(DOI:10.1159/000128292)

Mucosal Blood Flow and Modified Vascular Responses to Norepinephrine in the Stomach of Rats with Liver Cirrhosis

Kitano S. · Koyanagi N. · Sugimachi K. · Kobayashi M. · Inokuchi K.
Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/12/1981
Accepted: 11/23/1981
Published online: 4/18/2008

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: http://www.karger.com/ESR

Abstract

To observe changes in hemodynamics and vascular responses to norepinephrine in cases of liver cirrhosis, male WKA rats were given CCI4 subcutaneously. The portal venous pressure of these so-induced cirrhotic rats was significantly higher than that of the controls. There was an increase of mucosal blood flow and a lowering of peripheral vascular resistance of the stomach. After norepinephrine infusion, the gastric mucosal blood flow increased significantly in cirrhotic rats, whereas there was no significant change in controls. The aorta and the portal vein showed no difference in the vascular response to either norepinephrine or [K+]0. These results suggest that in cirrhotic rats there is an increase in blood flow and a lowering of peripheral vascular resistance in the gastric mucosa and that these hemodynamic changes may be derived from alteration in the vascular response to norepinephrine in gastric microcirculation.


  

Author Contacts

Seigo Kitano, Second Departement of Surgery, Faculty of Medicine, Kyushu University, Fukuoka (Japan)

  

Article Information

Received: October 12, 1981
Accepted: November 23, 1981
Published online: April 18, 2008
Number of Print Pages : 10

  

Publication Details

European Surgical Research (Clinical and Experimental Surgery)

Vol. 14, No. 3, Year 1982 (Cover Date: 1982)

Journal Editor: Kempski O. (Mainz)
ISSN: 0014–312X (Print), eISSN: 1421–9921 (Online)

For additional information: http://www.karger.com/ESR


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/12/1981
Accepted: 11/23/1981
Published online: 4/18/2008

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: http://www.karger.com/ESR


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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