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Vol. 14, No. 3, 1982
Issue release date: 1982
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Eur Surg Res 1982;14:221–230
(DOI:10.1159/000128292)
Original Paper

Mucosal Blood Flow and Modified Vascular Responses to Norepinephrine in the Stomach of Rats with Liver Cirrhosis

Kitano S. · Koyanagi N. · Sugimachi K. · Kobayashi M. · Inokuchi K.
Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan Eur Surg Res 1982;14:221–230 (DOI:10.1159/000128292)

Abstract

To observe changes in hemodynamics and vascular responses to norepinephrine in cases of liver cirrhosis, male WKA rats were given CCI4 subcutaneously. The portal venous pressure of these so-induced cirrhotic rats was significantly higher than that of the controls. There was an increase of mucosal blood flow and a lowering of peripheral vascular resistance of the stomach. After norepinephrine infusion, the gastric mucosal blood flow increased significantly in cirrhotic rats, whereas there was no significant change in controls. The aorta and the portal vein showed no difference in the vascular response to either norepinephrine or [K+]0. These results suggest that in cirrhotic rats there is an increase in blood flow and a lowering of peripheral vascular resistance in the gastric mucosa and that these hemodynamic changes may be derived from alteration in the vascular response to norepinephrine in gastric microcirculation.

 goto top of outline Author Contacts

Seigo Kitano, Second Departement of Surgery, Faculty of Medicine, Kyushu University, Fukuoka (Japan)


 goto top of outline Article Information

Received: October 12, 1981
Accepted: November 23, 1981
Published online: April 18, 2008
Number of Print Pages : 10


 goto top of outline Publication Details

European Surgical Research (Clinical and Experimental Surgery)

Vol. 14, No. 3, Year 1982 (Cover Date: 1982)

Journal Editor: Kempski O. (Mainz)
ISSN: 0014–312X (Print), eISSN: 1421–9921 (Online)

For additional information: http://www.karger.com/ESR


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