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Vol. 16, No. 5, 1984
Issue release date: 1984
Eur Surg Res 1984;16:288–293
Original Paper

A Microsurgical Method for Denervation of the Liver in the Rat

Holmin T.a · Ekelund M.a · Kullendorff C.-M.b · Lindfeldt J.a
Departments of aSurgery and bPediatric Surgery, University of Lund, Sweden


The role of the nerves in the hepato-duodenal ligament should be of special surgical interest, since these nerves are often injured in hepatic and biliary tract surgery. We have developed a microsurgical procedure for liver denervation. All visible nerves were resected after staining. Norepinephrine values in central liver tissue of denervated rats were only 18 % of the corresponding values in innervated liver tissue, indicating an appreciable degree of sympathetic denervation. No detectable immunoreactivity of gastrin, cholecystokinin, vasoactive intestinal polypeptide, substance P, somatostatin or enkephalin were found within resected hepatic nerves. The described denervation procedure is simple and reproducible. It can be used to obtain additional information about the nervous regulation of various liver functions.

 goto top of outline Author Contacts

T. Holmin, MD, Department of Surgery, University of Lund, S-221 85 Lund (Sweden)

 goto top of outline Article Information

Received: June 13, 1983
Accepted: October 17, 1983
Published online: April 18, 2008
Number of Print Pages : 6

 goto top of outline Publication Details

European Surgical Research (Clinical and Experimental Surgery)

Vol. 16, No. 5, Year 1984 (Cover Date: 1984)

Journal Editor: Kempski O. (Mainz)
ISSN: 0014–312X (Print), eISSN: 1421–9921 (Online)

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