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Vol. 147, No. 1, 2008
Issue release date: August 2008
Section title: Original Paper
Int Arch Allergy Immunol 2008;147:17–24
(DOI:10.1159/000128582)

Differential mRNA Expression of Antimicrobial Peptides and Proteins in Atopic Dermatitis as Compared to Psoriasis Vulgaris and Healthy Skin

Gambichler T. · Skrygan M. · Tomi N.S. · Othlinghaus N. · Brockmeyer N.H. · Altmeyer P. · Kreuter A.
Department of Dermatology, Ruhr-University Bochum, Bochum, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/18/2007
Accepted: 1/8/2008
Published online: 4/30/2008
Issue release date: August 2008

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: Patients with atopic dermatitis (AD) are prone to have skin infections. We aimed to investigate mRNA expression levels of various antimicrobial peptides and proteins (AMPs) in AD patients, and compare it with psoriasis vulgaris (PV) patients and healthy subjects. Methods: Skin biopsies were obtained from healthy subjects and patients with AD and PV. Quantitative real-time RT-PCR was used to determine the mRNA levels of human β-defensin (hBD)-1, hBD-2, hBD-3, LL-37, psoriasin, RNase 7, interferon-γ, and interleukin-10 (IL-10). Results: Except for LL-37, mRNA of hBDs, psoriasin, and RNase 7 was significantly higher expressed in AD (n = 42) and/or PV (n = 35) patients when compared to controls (n = 18). While PV lesions showed significantly higher mRNA hBD-2 levels than lesions of AD, the latter was associated with significantly higher mRNA levels of RNase 7 when compared to PV. A significant positive correlation of hBD expression was observed both in AD patients and PV patients. hBD mRNA levels of AD skin correlated with psoriasin and RNase 7 levels. hBD-1 mRNA expression correlated with AD activity and IL-10 mRNA expression. Conclusions: Most AMPs investigated in this study proved to be overexpressed in AD as well as PV when compared to controls. However, a statistically significant difference in AMP mRNA expression between AD and PV was only found for hBD-2 and RNase 7. A moderate-to-strong linear relationship between the mRNA expression of particular AMPs appears to exist in AD, and to a lesser extent in PV as well.

© 2008 S. Karger AG, Basel


  

Author Contacts

Correspondence to: Dr. Thilo Gambichler
Department of Dermatology, Ruhr University Bochum
Gudrunstrasse 56, DE–44791 Bochum (Germany)
Tel. +49 234 509 3459, Fax +49 234 509 3445
E-Mail t.gambichler@klinikum-bochum.de

  

Article Information

Received: July 18, 2007
Accepted after revision: January 8, 2008
Published online: April 30, 2008
Number of Print Pages : 8
Number of Figures : 6, Number of Tables : 1, Number of References : 22

  

Publication Details

International Archives of Allergy and Immunology

Vol. 147, No. 1, Year 2008 (Cover Date: August 2008)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018–2438 (Print), eISSN: 1423–0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/18/2007
Accepted: 1/8/2008
Published online: 4/30/2008
Issue release date: August 2008

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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