Journal Mobile Options
Table of Contents
Vol. 24, Suppl. 1, 1992
Issue release date: 1992
Eur Surg Res 1992;24:29–39
(DOI:10.1159/000129237)
Paper

Hormone-Induced Pancreatitis

Willemer S.a · Elsässer H.-P.b · Adler G.a
Departments of aInternal Medicine and bCell Biology, Philipps University, Marburg, FRG

Abstract

Intravenous infusion of the synthetic cholecystokinin analogue cerulein at a dose of 0.25 µg/kg/h causes maximal stimulation of pancreatic exocrine secretion. The infusion of supra-maximal doses of cerulein (5 and 10 µg/kg/h) induces a significant increase in pancreatic enzymes in blood, and interstitial edema and inflammatory cell infiltration. This model of hormone-induced pancreatitis works in rats, mice, dogs and hamsters. Besides intravenous infusion, repeated intraperitoneal injections can also be used for induction of pancreatitis. In the early phase of cerulein-induced pancreatitis, large autophagic vacuoles result from fusion of zymogen granules within the acinar cell. This is accompanied by an increase in lysosomal enzyme activity and activation of trypsinogen which finally leads to cellular necrosis. All animals survive the induction of pancreatitis. The pancreas completely regenerates within 6 days after induction of pancreatitis. This model of experimental pancreatitis favors the analysis of intracellular events in the early phase of pancreatitis.

 goto top of outline Author Contacts

Prof. Dr. Guido Adler, Zentrum für innere Medizin I, Universität Ulm, Robert-Koch-Strasse, D-W-7900 Ulm (FRG)


 goto top of outline Article Information

Published online: April 23, 2008
Number of Print Pages : 11


 goto top of outline Publication Details

European Surgical Research (Clinical and Experimental Surgery)

Vol. 24, No. Suppl. 1, Year 1992 (Cover Date: 1992)

Journal Editor: Kempski O. (Mainz)
ISSN: 0014–312X (Print), eISSN: 1421–9921 (Online)

For additional information: http://www.karger.com/ESR


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.