Effect of Pantothenic Acid and Ascorbic Acid Supplementation on Human Skin Wound Healing Process
A Double-Blind, Prospective and Randomized TrialVaxman F. · Olender S. · Lambert A. · Nisand G. · Aprahamian M. · Bruch J.F. · Didier E. · Volkmar P. · Grenier J.F.
INSERM U 61 et Laboratoire Pautrier, Chirurgie B, Hospices Civils, Strasbourg, France
This study aimed at testing human skin wound healing improvement by a 21-day supplementation of 1.0 g ascorbic acid (AA) and 0.2 g pantothenic acid (PA). 49 patients undergoing surgery for tattoos, by the successive resections procedure, entered a double-blind, prospective and randomized study. Tests performed on both skin and scars determined: hydroxyproline concentrations, number of fibroblasts, trace element contents and mechanical properties. In the 18 supplemented patients, it was shown that in skin (day 8) Fe increased (p < 0.05) and Mn decreased (p < 0.05); in scars (day 21), Cu (p = 0.07) and Mn (p < 0.01) decreased, and Mg (p < 0.05) increased; the mechanical properties of scars in group A were significantly correlated to their contents in Fe, Cu and Zn, whereas no correlation was shown in group B. In blood, AA increased after surgery with supplementation, whereas it decreased in controls. Although no major improvement of the wound healing process could be documented in this study, our results suggest that the benefit of AA and PA supplementation could be due to the variations of the trace elements, as they are correlated to mechanical properties of the scars.
Dr. F. Vaxman, Hôpitaux Universitaires de Strasbourg, Pavilion Chirurgical B, Hospices Civils, F-67091 Strasbourg Cedex (France)
Received: December 10, 1991
Accepted: August 5, 1994
Published online: April 23, 2008
Number of Print Pages : 9
European Surgical Research (Clinical and Experimental Surgery)
Vol. 27, No. 3, Year 1995 (Cover Date: 1995)
Journal Editor: Kempski O. (Mainz)
ISSN: 0014–312X (Print), eISSN: 1421–9921 (Online)
For additional information: http://www.karger.com/ESR