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Vol. 52, No. 4, 2008
Issue release date: September 2008
Section title: Original Paper
Ann Nutr Metab 2008;52:281–287
(DOI:10.1159/000129661)

Relative Bioavailability of Two Forms of a Novel Water-Soluble Coenzyme Q10

Žmitek J. · Šmidovnik A. · Fir M. · Prošek M. · Žmitek K. · Walczak J. · Pravst I.
aNational Institute of Chemistry, bHigher School of Applied Sciences, cJožef Stefan Institute, dFaculty of Chemistry and Chemical Technology, University of Ljubljana, and eValens Int., Ljubljana, Slovenia; fBIOFANA Spółka z o.o., Kutno, Poland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/20/2007
Accepted: 4/11/2008
Published online: 7/22/2008

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Background: Coenzyme Q10 (CoQ10) is a naturally occurring compound that plays a fundamental role in cellular bioenergetics and is an effective antioxidant. Numerous health benefits of CoQ10 supplementation have been reported, resulting in growing demands for its use in fortifying food. Due to its insolubility in water, the enrichment of most food products is not easily achievable and its in vivo bioavailability is known to be poor. Water solubility was increased significantly with the use of an inclusion complex with β-cyclodextrin. This complex is widely used as Q10Vital® in the food industry, while its in vivo absorption in humans has not previously been studied. Methods: A randomized three-period crossover clinical trial was therefore performed in which a single dose of CoQ10 was administered orally to healthy human subjects. The pharmacokinetic parameters of two forms of the novel CoQ10 material were determined and compared to soft-gel capsules with CoQ10 in soybean oil that acted as a reference. Results: The mean increase of CoQ10 plasma concentrations after dosing with Q10Vital® forms was determined to be over the reference formulation and the area under the curve values, extrapolated to infinity (AUCinf), were also higher with the tested forms; statistically significant 120 and 79% increases over the reference were calculated for the Q10Vital® liquid and powder, respectively. Conclusions: The study revealed that the absorption and bioavailability of CoQ10 in the novel formulations are significantly increased, probably due to the enhanced water solubility.


  

Author Contacts

Dr. Janko Žmitek
National Institute of Chemistry
Hajdrihova 19
SI–1000 Ljubljana (Slovenia)
Tel. +386 1 476 0347, Fax +386 1 476 0300, E-Mail janko.zmitek@ki.si

  

Article Information

Received: December 20, 2007
Accepted: April 11, 2008
Published online: July 22, 2008
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 2, Number of References : 47

  

Publication Details

Annals of Nutrition and Metabolism (Journal of Nutrition, Metabolic Diseases and Dietetics)

Vol. 52, No. 4, Year 2008 (Cover Date: September 2008)

Journal Editor: Elmadfa I. (Vienna)
ISSN: 0250–6807 (Print), eISSN: 1421–9697 (Online)

For additional information: http://www.karger.com/ANM


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/20/2007
Accepted: 4/11/2008
Published online: 7/22/2008

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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