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Table of Contents
Vol. 217, No. 2, 2008
Issue release date: August 2008
Section title: Clinical and Laboratory Studies
Dermatology 2008;217:107–113
(DOI:10.1159/000130425)

Calcipotriol plus Betamethasone Dipropionate Scalp Formulation Is Effective and Well Tolerated in the Treatment of Scalp Psoriasis: A Phase II Study

Buckley C.a · Hoffmann V.b · Shapiro J.d · Saari S.e · Cambazard F.f · Milsgaard M.c
aDepartment of Dermatology, Waterford Regional Hospital Ardkeen, Waterford, Ireland; bClinical Operations and cBiostatistics Department, LEO Pharma A/S, Ballerup, Denmark; dDepartment of Dermatology and Skin Science, University of British Columbia, Vancouver, B.C., Canada; ePoliclinic of Dermatology, Medical Reception Centre, Turku, Finland; fService de Dermatologie, CHU St-Etienne – Hôpital Nord, Saint-Etienne, France

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Studies

Received: December 22, 2007
Accepted: February 18, 2008
Published online: May 08, 2008
Issue release date: August 2008

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: There is a need for more effective therapy for scalp psoriasis. Objective: To assess the efficacy and safety of a 2-compound scalp formulation including calcipotriol and betamethasone dipropionate in the treatment of scalp psoriasis. Methods: Patients (n = 218) with scalp psoriasis were randomized to treatment with the 2-compound scalp formulation (n = 108) or betamethasone dipropionate in the same vehicle (n = 110). The treatments were applied once daily on the scalp for up to 8 weeks. Results: The 2-compound scalp formulation showed a significantly higher efficacy than betamethasone dipropionate on the total sign score at the end of treatment (p = 0.042) and after 2 weeks (p = 0.005). Conclusion: The calcipotriol plus betamethasone dipropionate scalp formulation was superior to betamethasone dipropionate in the same vehicle when used once daily for up to 8 weeks in the treatment of scalp psoriasis.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Studies

Received: December 22, 2007
Accepted: February 18, 2008
Published online: May 08, 2008
Issue release date: August 2008

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.