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Vol. 17, No. 4, 1976
Issue release date: 1976
Cytogenet Cell Genet 1976;17:200–211

Human mitochondrial NADP-dependent isocitrate dehydrogenase in man-mouse somatic cell hybrids

Bruns G.A.P. · Eisenman R.E. · Gerald P.S.
Division of Clinical Genetics, The Children’s Hospital Medical Center, and Department of Pediatrics, Harvard Medical School, Boston, Mass.


Human mitochondrial NADP-dependent isocitrate dehydrogenase (IDH-2) is expressed in man-mouse somatic cell hybrids as a dimeric molecule. The gene specifing this enzyme was observed to be syntenic with the mannose phosphate isomerase locus in the 56 primary man-mouse clones in this series. The human IDH-2 locus, therefore, may be assigned to chromosome 15.

 goto top of outline Author Contacts

Request reprints from: Dr. Gail A.P. Bruns, Division of Clinical Genetics, The Children’s Hospital Medical Center, 300 Longwood Avenue, Boston, MA 02115 (USA).

 goto top of outline Article Information

Manuscript received: 20 April 1976
Published online: May 02, 2008
Number of Print Pages : 12

 goto top of outline Publication Details

Cytogenetic and Genome Research

Vol. 17, No. 4, Year 1976 (Cover Date: 1976)

Journal Editor: Schmid M. (Würzburg)
ISSN: 1424–8581 (Print), eISSN: 1424–859X (Online)

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