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Vol. 26, No. 1, 1980
Issue release date: 1980
Cytogenet Cell Genet 1980;26:36–40
Original Article

Yeast stimulation of bone marrow mitosis for cytogenetic investigations

Lee M.R. · Elder F.F.B.
Department of Ecology, Ethology, and Evolution, University of Illinois, Urbana, Ill.


We report a simple, dependable method for stimulating bone marrow mitosis in small mammals. Subcutaneous injections of a suspension of active baker’s yeast may elevate the mitotic index as much as six times or more. Additionally, the metaphases obtained are easily spread when air dried, and the chromosomes are readily banded. This method should prove useful to investigators who wish to use bone marrow as a source of chromosomes for cytotaxonomic studies or for studies of specific chromosome damage in vivo.

 goto top of outline Author Contacts

Request reprints from: Dr. M. Raymond Lee, Department of Ecology, Ethology, and Evolution, College of Liberal Arts and Sciences, University of Illinois, Urbana, IL 61801 (USA).

 goto top of outline Article Information

Received:: 17 May 1979
Published online: May 06, 2008
Number of Print Pages : 5

 goto top of outline Publication Details

Cytogenetic and Genome Research

Vol. 26, No. 1, Year 1980 (Cover Date: 1980)

Journal Editor: Schmid M. (Würzburg)
ISSN: 1424–8581 (Print), eISSN: 1424–859X (Online)

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