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Cover

Dermatologic Immunity

Editor(s): Nickoloff B.J. (Chicago, Ill.) 
Nestle F.O. (London) 
Table of Contents
Vol. 10, No. , 2008
Section title: Paper
Nickoloff BJ, Nestle FO (eds): Dermatologic Immunity. Curr Dir Autoimmun. Basel, Karger, 2008, vol 10, pp 76-118
(DOI:10.1159/000131450)

Atopic Dermatitis in 2008

Chan L.
University of Illinois College of Medicine, Chicago, Ill., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: May 07, 2008
Cover Date: 2008

Number of Print Pages: 43
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8391-6 (Print)
eISBN: 978-3-8055-8392-3 (Online)

Abstract

Atopic dermatitis (also termed atopic eczema and infantile eczema), a chronic, itchy, inflammatory skin disease that sets on at infancy or early childhood, is observed with increasing prevalence around the world, particularly in developed nations. Although sufficient evidences are not yet available to define it as a classical autoimmune disease, autoantigens have been identified. Investigations of atopic dermatitis in human patients and animal models suggest that this disease is initiated, maintained and perpetuated by the actions of cytokines, chemokines, T cells, antigen-presenting cells and other inflammatory cells; there is also evidence of skin barrier defect and angiogenesis. Recent identification of mutations of the epidermal barrier protein filaggrin (encoded by FLG), present in about 9% of people of European origin, with 70% of individuals homozygous or compound heterozygous for FLG null alleles developing atopic dermatitis, provides a strong link between a defect of the epidermal barrier that allows easy penetration of pathogen/allergen through the skin and a systemic hyperactive immune response to the penetrated pathogen/allergen. The newly introduced concept of ‘intrinsic’ and ‘extrinsic’ atopic dermatitis has fueled the debate among academic dermatologists as to how ‘atopic’ atopic dermatitis should be defined. Some recent advancements on the management options for atopic dermatitis are also discussed.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: May 07, 2008
Cover Date: 2008

Number of Print Pages: 43
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8391-6 (Print)
eISBN: 978-3-8055-8392-3 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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