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Table of Contents
Vol. 27, No. 2-3, 1980
Issue release date: 1980
Section title: Original Article
Cytogenet Cell Genet 1980;27:168–175
(DOI:10.1159/000131478)

Assignment of the gene for human neutral alpha-glucosidase C to chromosome 15

Martiniuk F.a · Hirschhorn R.b · Smith M.c
aDepartment of Biology, New York University Graduate School of Arts and Science, bDepartment of Medicine, New York University School of Medicine, and cDivision of Human Genetics, Department of Pediatrics, Mount Sinai School of Medicine, New York, N.Y.

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Accepted: October 04, 1979
Published online: May 06, 2008
Issue release date: 1980

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Human neutral α-glucosidase C (GANC) can be separated from the homologous mouse isozyme by starch gel electrophoresis at pH 6.5. A total of 40 clones (13 primary and 27 secondary) were derived from eight separate hybridization experiments between the mouse HPRT deficient RAG cell line and eight different human long term lymphoid cell lines or fetal cells. The thirteen primary clones showed 100% concordance between the expression of the human enzyme and the presence or absence of human chromosome 15. Analysis of the 27 secondary clones showed only two subclones discordant for segregation of human GANC and enzyme markers for 15. The two apparently discordant clones for human GANC were both derived from the same RAG × human fetal lung primary clone, and both lacked GANC activity, while retaining a 15. Since human GANC is polymorphic with a null allele at high frequency (Martiniuk and Hirschhorn, 1980), it is possible that these subclones carried one chromosome with a null allele for GANC. Alternatively there could been an undetected chromosome break between the GANC locus and the loci of the marker enzymes. Whatever the reason for the two apparently discordant subclones, combined data from all 40 clones show 95% concordant segregation for human GANC and No. 15.

© 1980 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Article

Accepted: October 04, 1979
Published online: May 06, 2008
Issue release date: 1980

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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