Cover

Dermatologic Immunity

Editor(s): Nickoloff B.J. (Chicago, Ill.) 
Nestle F.O. (London) 
Table of Contents
Vol. 10, No. , 2008
Section title: Paper
Nickoloff BJ, Nestle FO (eds): Dermatologic Immunity. Curr Dir Autoimmun. Basel, Karger, 2008, vol 10, pp 244-257
(DOI:10.1159/000131501)

The Genetics of Generalized Vitiligo

Spritz R.
Human Medical Genetics Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colo., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 5/7/2008
Cover Date: 2008

Number of Print Pages: 14
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8391-6 (Print)
eISBN: 978-3-8055-8392-3 (Online)

Abstract

Generalized vitiligo is an acquired disorder in which patches of depigmented skin, overlying hair and oral mucosa result from progressive autoimmune loss of melanocytes from the involved areas. Perhaps the most common pigmentary disorder, vitiligo results from a complex interaction of environmental, genetic and immunologic factors that ultimately contribute to melanocyte destruction, resulting in the characteristic depigmented lesions. In the past few years, studies of the genetic epidemiology of generalized vitiligo have led to the recognition that vitiligo is part of a broader, genetically determined, autoimmune and autoinflammatory diathesis. Attempts to identify genes involved in vitiligo susceptibility have involved gene expression studies, allelic association studies of candidate genes and genome-wide linkage analyses to discover new genes, and these studies have begun to shed light on the mechanisms of vitiligo pathogenesis. It is anticipated that the discovery of biological pathways of vitiligo pathogenesis will provide novel therapeutic and prophylactic targets for future approaches to the treatment and prevention of vitiligo and its associated autoimmune diseases.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 5/7/2008
Cover Date: 2008

Number of Print Pages: 14
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8391-6 (Print)
eISBN: 978-3-8055-8392-3 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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