Generalized vitiligo is an acquired disorder in which patches of depigmented skin, overlying
hair and oral mucosa result from progressive autoimmune loss of melanocytes from the
involved areas. Perhaps the most common pigmentary disorder, vitiligo results from a complex
interaction of environmental, genetic and immunologic factors that ultimately contribute
to melanocyte destruction, resulting in the characteristic depigmented lesions. In the past few
years, studies of the genetic epidemiology of generalized vitiligo have led to the recognition
that vitiligo is part of a broader, genetically determined, autoimmune and autoinflammatory
diathesis. Attempts to identify genes involved in vitiligo susceptibility have involved gene
expression studies, allelic association studies of candidate genes and genome-wide linkage
analyses to discover new genes, and these studies have begun to shed light on the mechanisms
of vitiligo pathogenesis. It is anticipated that the discovery of biological pathways of vitiligo
pathogenesis will provide novel therapeutic and prophylactic targets for future approaches to
the treatment and prevention of vitiligo and its associated autoimmune diseases.
Copyright / Drug Dosage
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