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Vol. 25, No. 6, 2008
Issue release date: July 2008
Section title: Original Research Article
Dement Geriatr Cogn Disord 2008;25:524–530
(DOI:10.1159/000131665)

Cerebral Substrates Related to Impaired Performance in the Clock-Drawing Test in Dementia with Lewy Bodies

Nagahama Y. · Okina T. · Suzuki N. · Matsuda M.
Department of Geriatric Neurology, Shiga Medical Center, Moriyama, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 4/3/2008
Published online: 5/13/2008

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Aims: To identify the neural correlates of impaired performance in the clock-drawing test (CDT) in patients with dementia with Lewy bodies (DLB). Methods: Cerebral blood flow was measured by single photon emission computed tomography in patients with clinically diagnosed DLB, and was compared between impaired CDT (n = 30) and normal CDT (n = 30) subgroups. Results: DLB patients with impaired CDT performance showed significantly lower cerebral blood flow in the bilateral frontal eye fields, supplementary eye fields, right posterior putamen and the right ventrolateral part of the thalamus relative to the normal CDT subgroup. Performance in other visuospatial/attentional tasks (trail making test part A, copying a cube, semantic fluency, and block design) was also poorer in the impaired CDT group than the normal CDT group. Conclusions: This study indicates that impaired performances on the CDT and some visuospatial/attentional tasks by DLB patients are closely related to dysfunctions of the frontal-subcortical network relevant to control of visuospatial attention and arousal, involving the frontal eye fields, supplementary eye fields and the thalamus. Our findings provide evidence that cognitive performance in DLB reflects the pathological involvement of both cortical and subcortical regions, and suggest that the neurophysiological basis underlying impaired CDT in DLB may be different from that in Alzheimer disease.


  

Author Contacts

Yasuhiro Nagahama
Department of Geriatric Neurology, Shiga Medical Center
5-4-30 Moriyama, Moriyama City, Shiga 524-8524 (Japan)
Tel. +81 77 582 5031, Fax +81 77 582 5426
E-Mail ynaga@pop12.odn.ne.jp

  

Article Information

Accepted: March 4, 2008
Published online: May 13, 2008
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 2, Number of References : 46

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 25, No. 6, Year 2008 (Cover Date: July 2008)

Journal Editor: Chan-Palay V. (New York, N.Y.)
ISSN: 1420–8008 (Print), eISSN: 1421–9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 4/3/2008
Published online: 5/13/2008

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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