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Table of Contents
Vol. 25, No. 6, 2008
Issue release date: June 2008
Section title: Original Paper
Cerebrovasc Dis 2008;25:539–547
(DOI:10.1159/000131672)

Association between Metabolic Syndrome and Risk of Stroke: A Meta-Analysis of Cohort Studies

Li W.a, b · Ma D.b · Liu M.a · Liu H.a · Feng S.a · Hao Z.a · Wu B.a · Zhang S.a
aDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, and bDepartment of Neurology, Yanan University Affiliated Hospital, Yanan, PR China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 21, 2007
Accepted: November 21, 2007
Published online: May 15, 2008
Issue release date: June 2008

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 3

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background: Our purpose was to investigate the association between metabolic syndrome and risk of stroke by meta-analysis. Methods: Electronic databases through July 2007 were searched to identify prospective cohort studies that examined the association between metabolic syndrome and risk of stroke. Two reviewers independently assessed eligibility and used a standardized form to collect data from published studies. The study quality was assessed by the Newcastle-Ottawa Scale. Results: We found 13 eligible studies that included 92,732 participants.Compared to individuals without metabolic syndrome, subjects with metabolic syndrome had a 1.6-fold increased risk of stroke (95% CI, 1.48–1.75). The relative risk of stroke associated with metabolic syndrome was 2.2 in the studies using the World Health Organization definition and 1.6 in those using the Adult Treatment Panel III definition, but the difference was not statistically significant. Conclusions: This analysis shows that metabolic syndrome is an important risk factor for incident stroke. A diagnosis of metabolic syndrome may prove useful in clinical management, and its elements should ultimately become important therapeutic targets for the reduction of the stroke burden in the general population.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 21, 2007
Accepted: November 21, 2007
Published online: May 15, 2008
Issue release date: June 2008

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 3

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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