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Cover

Dermatologic Immunity

Editor(s): Nickoloff B.J. (Chicago, Ill.) 
Nestle F.O. (London) 
Table of Contents
Vol. 10, No. , 2008
Section title: Paper
Nickoloff BJ, Nestle FO (eds): Dermatologic Immunity. Curr Dir Autoimmun. Basel, Karger, 2008, vol 10, pp 313-332
(DOI:10.1159/000131751)

Dermatomyositis

Krathen M.a · Fiorentino D.b · Werth V.a,c
aDepartment of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pa.; p Department of Dermatology, Stanford University School of Medicine, Stanford, Calif.; c Philadelphia VA Medical Center, Philadelphia, Pa., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: May 07, 2008
Cover Date: 2008

Number of Print Pages: 20
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8391-6 (Print)
eISBN: 978-3-8055-8392-3 (Online)

Abstract

Dermatomyositis (DM) is a chronic inflammatory disorder of the skin and muscles. Although thought to be autoimmune in origin, many questions remain as to the etiopathogenesis of this disease. DM has classically been considered a humorally mediated disease. Current evidence, however, seems to increasingly support alternative (though not mutually exclusive) mechanisms of pathogenesis, including cell-mediated and innate immune system dysfunction. Pathologic findings of DM in muscle include infarcts, perifascicular atrophy, endothelial cell swelling and necrosis, vessel wall membrane attack complex deposition, and myocyte-specific MHC I upregulation. As for the skin, histopathologic findings include hyperkeratosis, epidermal basal cell vacuolar degeneration and apoptosis, increased dermal mucin deposition, and a cell-poor interface dermatitis. Autoantibodies, particularly those that bind nuclear or cytoplasmic ribonucleoprotein antigens, are also commonly found in DM, although their importance in pathogenesis remains unclear. Defective cellular clearance, genetic predilection and environmental exposures, such as viral infection, may also play an important role in the pathogenesis of DM. The seminal work regarding the pathogenesis of DM is reviewed and an update on the recent basic and molecular advances in the field is provided.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: May 07, 2008
Cover Date: 2008

Number of Print Pages: 20
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8391-6 (Print)
eISBN: 978-3-8055-8392-3 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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