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Table of Contents
Vol. 42, No. 1-2, 1986
Issue release date: 1986
Section title: Original Article
Cytogenet Cell Genet 1986;42:94–98
(DOI:10.1159/000132258)

The gene for human transforming growth factor α is on the short arm of chromosome 2

Tricoli J.V. · Nakai H. · Byers M.G. · Rall LB. · Bell G.I. · Shows T.B.
Department of Human Genetics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, NY, and Chiron Corporation, Emeryville, CA

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Accepted: December 02, 1985
Published online: May 08, 2008
Issue release date: 1986

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Transforming growth factor α is a polypeptide growth factor that participates in the reversible transformation of cells in vitro and is secreted by many transformed cell lines. It also shares sequence and functional homologies with epidermal growth factor. Working with a cloned cDNA probe (λhTGFl-10) and derivatives, we have mapped this gene (TGFA) to 2p13 with the use of somatic cell hybrids and in situ hybridization. This is the same region involved in the 2;8 translocations of Burkitt lymphoma. Such a rearrangement could orient c-myc (8q24) adjacent to TGFA, resulting in activation of one or both of these genes.

© 1986 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Article

Accepted: December 02, 1985
Published online: May 08, 2008
Issue release date: 1986

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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