We report the chromosomal assignment on chromosome arm 16p of a cDNA clone isolated through its expression in mature kidney and lack of expression in several Wilms tumors. DNA sequencing and analysis of the pattern of RNA expression in different tissues identified this clone as a uromodulin (Tamm-Horsfall glycoprotein, uromucoid; UMOD) sequence. By hybridizing this clone to somatic cell hybrids carrying different human chromosomes or segments of chromosome 16 the gene for UMOD was localized to 16p13.11.
Request reprints from Dr. Claudine Junien, INSERM U73, Chateau de Longchamp, Bois de Boulogne, 75016 Paris (France).
Received: 23 July 1992
Published online: May 14, 2008
Number of Print Pages : 3
Cytogenetic and Genome Research
Vol. 62, No. 4, Year 1993 (Cover Date: 1993)
Journal Editor: Schmid M. (Würzburg)
ISSN: 1424–8581 (Print), eISSN: 1424–859X (Online)
For additional information: http://www.karger.com/CGR
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