Journal Mobile Options
Table of Contents
Vol. 62, No. 4, 1993
Issue release date: 1993
Cytogenet Cell Genet 1993;62:214–216
Gene Mapping, Cloning, and Sequencing

Assignment of the human gene for pregnancy-associated plasma protein A (PAPPA) to 9q33.1 by fluorescence in situ hybridization to mitotic and meiotic chromosomes

Silahtaroglu A.N.ab · Tümer Z.a · Kristensen T.c · Sottrup-Jensen L.d · Tommerup
aThe Danish Center for Human Genome Research, The John F. Kennedy Institute, Glostrup (Denmark); bDivision of Biomedical Sciences, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul (Turkey); cDepartment of Chemistry and dDepartment of Molecular Biology, University of Aarhus, Aarhus (Denmark); and eDepartment of Medical Genetics, Ullevaal Hospital, Oslo (Norway) Cytogenet Cell Genet 1993;62:214–216 (DOI:10.1159/000133479)


Low levels of pregnancy-associated plasma protein A (PAPPA) during the first trimester has been suggested as a biochemical indicator of pregnancies with aneuploid fetuses. Furthermore, the complete absence of PAPPA in pregnancies associated with Cornelia de Lange syndrome (CL) has suggested a causal connection between PAPPA and the development of CL. We have assigned the locus for PAPPA to chromosome region 9q33.1 on mitotic and meiotic chromosomes by fluorescence in situ hybridization, using a 3.7-kb partial PAPPA cDNA probe.

 goto top of outline Author Contacts

Request reprints from Dr. N. Tommerup, The John F. Kennedy Institute, Gl. Landevej 7, DK-2600 Glostrup (Denmark); fax: +45 43431130.

 goto top of outline Article Information

Received: 24 June 1992
Published online: May 14, 2008
Number of Print Pages : 3

 goto top of outline Publication Details

Cytogenetic and Genome Research

Vol. 62, No. 4, Year 1993 (Cover Date: 1993)

Journal Editor: Schmid M. (Würzburg)
ISSN: 1424–8581 (Print), eISSN: 1424–859X (Online)

For additional information:

Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.