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Vol. 62, No. 4, 1993
Issue release date: 1993
Cytogenet Cell Genet 1993;62:214–216
(DOI:10.1159/000133479)
Gene Mapping, Cloning, and Sequencing

Assignment of the human gene for pregnancy-associated plasma protein A (PAPPA) to 9q33.1 by fluorescence in situ hybridization to mitotic and meiotic chromosomes

Silahtaroglu A.N.ab · Tümer Z.a · Kristensen T.c · Sottrup-Jensen L.d · Tommerup N.ae
aThe Danish Center for Human Genome Research, The John F. Kennedy Institute, Glostrup (Denmark); bDivision of Biomedical Sciences, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul (Turkey); cDepartment of Chemistry and dDepartment of Molecular Biology, University of Aarhus, Aarhus (Denmark); and eDepartment of Medical Genetics, Ullevaal Hospital, Oslo (Norway) Cytogenet Cell Genet 1993;62:214–216 (DOI:10.1159/000133479)

Abstract

Low levels of pregnancy-associated plasma protein A (PAPPA) during the first trimester has been suggested as a biochemical indicator of pregnancies with aneuploid fetuses. Furthermore, the complete absence of PAPPA in pregnancies associated with Cornelia de Lange syndrome (CL) has suggested a causal connection between PAPPA and the development of CL. We have assigned the locus for PAPPA to chromosome region 9q33.1 on mitotic and meiotic chromosomes by fluorescence in situ hybridization, using a 3.7-kb partial PAPPA cDNA probe.

 goto top of outline Author Contacts

Request reprints from Dr. N. Tommerup, The John F. Kennedy Institute, Gl. Landevej 7, DK-2600 Glostrup (Denmark); fax: +45 43431130.


 goto top of outline Article Information

Received: 24 June 1992
Published online: May 14, 2008
Number of Print Pages : 3


 goto top of outline Publication Details

Cytogenetic and Genome Research

Vol. 62, No. 4, Year 1993 (Cover Date: 1993)

Journal Editor: Schmid M. (Würzburg)
ISSN: 1424–8581 (Print), eISSN: 1424–859X (Online)

For additional information: http://www.karger.com/CGR


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