Journal Mobile Options
Table of Contents
Vol. 64, No. 3-4, 1993
Issue release date: 1993
Cytogenet Cell Genet 1993;64:208–209
(DOI:10.1159/000133577)
Gene Mapping, Cloning, and Sequencing

Mapping of the bone morphogenetic protein 1 gene (BMP1) to 8p21: removal of BMP1 from candidacy for the bone disorder in Langer-Giedion syndrome

Yoshiura K.a · Tamura T.a,b · Hong H.-S.c · Ohta T.a · Soejima H.a · Kishino T.a · Jinno Y.a · Niikawa N.a
aDepartment of Human Genetics, Nagasaki University School of Medicine, Nagasaki (Japan), bDepartment of Child Development, Kumamoto University School of Medicine, Kumamoto (Japan), and cDepartment of Anatomy, Kyungpook National University College of Medicine, Taegu (Korea)

Abstract

Fifteen cosmids containing sequences from the human bone moφhogenetic protein 1 gene (BMPl) were isolated from a cosmid library. The probe was a 483-bp DNA obtained by the reverse transcriptase-PCR method using primers designed according to the reported BMP 1 sequence. When the positive cosmids were tested for chromosome fluorescence in situ hybridization, all showed signals at 8p21. The results indicated that BMPl is not responsible for Langer-Giedion syndrome, whose putative gene has been assigned to 8q24.

 goto top of outline Author Contacts

Request reprints from Koh-ichiro Yoshiura, MD, Department of Human Genetics, Nagasaki University School of Medicine, Sakamoto 1-12-4, Nagasaki 852 (Japan). Telephone 81-958-47-2111, ext 2387; fax 81-958-44-2658.


 goto top of outline Article Information

Received 15 January 1993
Published online: May 14, 2008
Number of Print Pages : 2


 goto top of outline Publication Details

Cytogenetic and Genome Research

Vol. 64, No. 3-4, Year 1993 (Cover Date: 1993)

Journal Editor: Schmid M. (Würzburg)
ISSN: 1424–8581 (Print), eISSN: 1424–859X (Online)

For additional information: http://www.karger.com/CGR


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.