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Vol. 64, No. 3-4, 1993
Issue release date: 1993
Cytogenet Cell Genet 1993;64:208–209
Gene Mapping, Cloning, and Sequencing

Mapping of the bone morphogenetic protein 1 gene (BMP1) to 8p21: removal of BMP1 from candidacy for the bone disorder in Langer-Giedion syndrome

Yoshiura K.a · Tamura T.a,b · Hong H.-S.c · Ohta T.a · Soejima H.a · Kishino T.a · Jinno Y.a · Niikawa N.a
aDepartment of Human Genetics, Nagasaki University School of Medicine, Nagasaki (Japan), bDepartment of Child Development, Kumamoto University School of Medicine, Kumamoto (Japan), and cDepartment of Anatomy, Kyungpook National University College of Medicine, Taegu (Korea)


Fifteen cosmids containing sequences from the human bone moφhogenetic protein 1 gene (BMPl) were isolated from a cosmid library. The probe was a 483-bp DNA obtained by the reverse transcriptase-PCR method using primers designed according to the reported BMP 1 sequence. When the positive cosmids were tested for chromosome fluorescence in situ hybridization, all showed signals at 8p21. The results indicated that BMPl is not responsible for Langer-Giedion syndrome, whose putative gene has been assigned to 8q24.

 goto top of outline Author Contacts

Request reprints from Koh-ichiro Yoshiura, MD, Department of Human Genetics, Nagasaki University School of Medicine, Sakamoto 1-12-4, Nagasaki 852 (Japan). Telephone 81-958-47-2111, ext 2387; fax 81-958-44-2658.

 goto top of outline Article Information

Received 15 January 1993
Published online: May 14, 2008
Number of Print Pages : 2

 goto top of outline Publication Details

Cytogenetic and Genome Research

Vol. 64, No. 3-4, Year 1993 (Cover Date: 1993)

Journal Editor: Schmid M. (Würzburg)
ISSN: 1424–8581 (Print), eISSN: 1424–859X (Online)

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