Journal Mobile Options
Table of Contents
Vol. 65, No. 3, 1994
Issue release date: 1994
Cytogenet Cell Genet 1994;65:177–178
Gene Mapping, Cloning, and Sequencing

Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34

Muresu R.a · Baldini A.b · Gress T.b · Posner J.B.c · Furneaux H.M.c · Siniscalco M.a,b
aPorto Conte Research and Training Laboratories, Istituto di Genetica Molecolare del CNR, Alghero (Italy); bImperial Cancer Research Fund, London (UK); and cMemorial Sloan-Kettering Cancer Center, New York, NY (USA).


A cDNA clone coding for a human brain protein (HuD), which is highly homologous to the Drosophila neuronal determination protein Elav and elicits antibody formation in a high proportion of patients with paraneoplastic encephalomyelitis, was used to isolate a λ phage recombinant clone, including a large fragment of the relevant human genomic region. The fragment proved to be an efficient probe for the precise subregional mapping of the gene by molecular in situ hybridization onto extended human prometaphase chromosomes. Analysis of banded metaphases with clear hybridization signals pointed unequivocally to the localization of the HuD gene to human chromosome band 1p34.

 goto top of outline Author Contacts

Request reprints from Dr. Marcello Siniscalco, Imperial Cancer Research Fund, Room A5, PO Box 123, Lincoln’s Inn Fields, London WC2A 3PX (UK); telephone: 44-71-269-3053; fax: 44-71-269-3479.

 goto top of outline Article Information

Received: 5 April 1993
Published online: May 14, 2008
Number of Print Pages : 2

 goto top of outline Publication Details

Cytogenetic and Genome Research

Vol. 65, No. 3, Year 1994 (Cover Date: 1994)

Journal Editor: Schmid M. (Würzburg)
ISSN: 1424–8581 (Print), eISSN: 1424–859X (Online)

For additional information:

Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.