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Vol. 65, No. 3, 1994
Issue release date: 1994
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Cytogenet Cell Genet 1994;65:177–178
(DOI:10.1159/000133626)
Gene Mapping, Cloning, and Sequencing

Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34

Muresu R.a · Baldini A.b · Gress T.b · Posner J.B.c · Furneaux H.M.c · Siniscalco M.a,b
aPorto Conte Research and Training Laboratories, Istituto di Genetica Molecolare del CNR, Alghero (Italy); bImperial Cancer Research Fund, London (UK); and cMemorial Sloan-Kettering Cancer Center, New York, NY (USA). Cytogenet Cell Genet 1994;65:177–178 (DOI:10.1159/000133626)

Abstract

A cDNA clone coding for a human brain protein (HuD), which is highly homologous to the Drosophila neuronal determination protein Elav and elicits antibody formation in a high proportion of patients with paraneoplastic encephalomyelitis, was used to isolate a λ phage recombinant clone, including a large fragment of the relevant human genomic region. The fragment proved to be an efficient probe for the precise subregional mapping of the gene by molecular in situ hybridization onto extended human prometaphase chromosomes. Analysis of banded metaphases with clear hybridization signals pointed unequivocally to the localization of the HuD gene to human chromosome band 1p34.

 goto top of outline Author Contacts

Request reprints from Dr. Marcello Siniscalco, Imperial Cancer Research Fund, Room A5, PO Box 123, Lincoln’s Inn Fields, London WC2A 3PX (UK); telephone: 44-71-269-3053; fax: 44-71-269-3479.


 goto top of outline Article Information

Received: 5 April 1993
Published online: May 14, 2008
Number of Print Pages : 2


 goto top of outline Publication Details

Cytogenetic and Genome Research

Vol. 65, No. 3, Year 1994 (Cover Date: 1994)

Journal Editor: Schmid M. (Würzburg)
ISSN: 1424–8581 (Print), eISSN: 1424–859X (Online)

For additional information: http://www.karger.com/CGR


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