A cDNA clone coding for a human brain protein (HuD), which is highly homologous to the
neuronal determination protein Elav and elicits antibody formation in a high proportion of patients with paraneoplastic encephalomyelitis, was used to isolate a λ phage recombinant clone, including a large fragment of the relevant human genomic region. The fragment proved to be an efficient probe for the precise subregional mapping of the gene by molecular in situ hybridization onto extended human prometaphase chromosomes. Analysis of banded metaphases with clear hybridization signals pointed unequivocally to the localization of the HuD gene to human chromosome band 1p34.
Request reprints from Dr. Marcello Siniscalco, Imperial Cancer Research Fund, Room A5, PO Box 123, Lincoln’s Inn Fields, London WC2A 3PX (UK); telephone: 44-71-269-3053; fax: 44-71-269-3479.
Received: 5 April 1993
Published online: May 14, 2008
Number of Print Pages : 2
Cytogenetic and Genome Research
Vol. 65, No. 3, Year 1994 (Cover Date: 1994)
Journal Editor: Schmid M. (Würzburg)
ISSN: 1424–8581 (Print), eISSN: 1424–859X (Online)
For additional information: http://www.karger.com/CGR
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