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Vol. 66, No. 2, 1994
Issue release date: 1994
Section title: Animal Cytogenetics and Comparative Mapping
Cytogenet Cell Genet 1994;66:99–103
(DOI:10.1159/000133676)

A mammalian homologue of Drosophila heterochromatin protein 1 (HP1) is a component of constitutive heterochromatin

Wreggett K.A. · Hill F. · James P.S. · Hutchings A. · Butcher G.W. · Singh P.B.
aCell Determination Group, Department of Development and Signalling, bMonoclonal Antibody Unit, Department of Immunology, and cConfocal Microscope Facility, Department of Cellular Physiology, AFRC Babraham Institute, Babraham, Cambridge, and dMRC Laboratory of Molecular Biology, Cambridge (UK)

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Article / Publication Details

First-Page Preview
Abstract of Animal Cytogenetics and Comparative Mapping

Accepted: 8/11/1993
Published online: 5/15/2008

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

The Drosophila HP1 gene contains a highly conserved sequence, the chromobox, which can be used to isolate HP1-like genes from both mouse (M31 and M32) and man (HSM1) (Singh et al., 1991). Here we report that a monoclonal antibody (MoAb) raised against the M31 protein recognises a 26-kDa protein in murine and human nuclear extracts and localises to large masses of condensed chromatin within murine interphase nuclei, some of which are associated with the nucleoli. At metaphase, the MoAb binds to the centromeres of both human and murine chromosomes. The evolutionary conservation of this chromosomal localisation indicates that the M31 protein is likely to be important in the packaging of mammalian chromosomal DNA into constitutive heterochromatin.


  

Author Contacts

Request reprints from Dr. P.B. Singh, Cell Determination Group, Department of Development and Signalling, AFRC Babraham Institute, Babraham, Cambridge CB2 4AT (UK). Present address of K.A. W.: The Faculty of Pharmacy, 19 Russell Street, University of Toronto, Toronto, Ontario M5S 2S2 (Canada).

  

Article Information

Received: 11 August 1993
Published online: May 15, 2008
Number of Print Pages : 5

  

Publication Details

Cytogenetic and Genome Research

Vol. 66, No. 2, Year 1994 (Cover Date: 1994)

Journal Editor: Schmid M. (Würzburg)
ISSN: 1424–8581 (Print), eISSN: 1424–859X (Online)

For additional information: http://www.karger.com/CGR


Article / Publication Details

First-Page Preview
Abstract of Animal Cytogenetics and Comparative Mapping

Accepted: 8/11/1993
Published online: 5/15/2008

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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